The N-terminal sequence affects distant helix interactions in hemoglobin. Implications for mutant proteins from studies on recombinant hemoglobin felix.
Dumoulin A, Padovan JC, Manning LR, Popowicz A, Winslow RM, Chait BT, Manning JM.
Dumoulin A, et al.
J Biol Chem. 1998 Dec 25;273(52):35032-8. doi: 10.1074/jbc.273.52.35032.
J Biol Chem. 1998.
PMID: 9857036
Free article.
Even though Hb Felix contains the HbA amino acids at its tetramer-dimer interface, which is located at a distance from the substitution sites, its interface properties resemble those of HbF. Therefore, the N-terminal sequence and not just those amino acids directly involve …
Even though Hb Felix contains the HbA amino acids at its tetramer-dimer interface, which is located at a distance from the substituti …