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Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancer.
Severson TM, Minnee E, Zhu Y, Schuurman K, Nguyen HM, Brown LG, Hakkola S, Menezes R, Gregoricchio S, Kim Y, Kneppers J, Linder S, Stelloo S, Lieftink C, van der Heijden MS, Nykter M, van der Noort V, Sanders J, Morris B, Jenster G, van Leenders GJ, Pomerantz M, Freedman ML, Beijersbergen RL, Urbanucci A, Wessels L, Nelson PS, Corey E, Prekovic S, Zwart W, Bergman AM. Severson TM, et al. Cell Rep Med. 2025 Jun 27:102215. doi: 10.1016/j.xcrm.2025.102215. Online ahead of print. Cell Rep Med. 2025. PMID: 40609538 Free article.
Genomic and transcriptomic features of androgen receptor signaling inhibitor resistance in metastatic castration-resistant prostate cancer.
Zhu X, Farsh T, Vis D, Yu I, Li H, Liu T, Sjöström M, Shrestha R, Kneppers J, Severson T, Zhang M, Lundberg A, Moreno Rodriguez T, Weinstein AS, Foye A, Mehra N, Aggarwal RR, Bergman AM, Small EJ, Lack NA, Zwart W, Quigley DA, van der Heijden MS, Feng FY. Zhu X, et al. Among authors: severson t. J Clin Invest. 2024 Aug 13;134(19):e178604. doi: 10.1172/JCI178604. J Clin Invest. 2024. PMID: 39352383 Free PMC article.
Grade Group 1 Prostate Cancers Exhibit Tumor-defining Androgen Receptor-driven Programs.
Linder S, Severson TM, van der Mijn KJC, Nevedomskaya E, Siefert JC, Stelloo S, Pomerantz MM, Freedman ML, van der Poel H, Jerónimo C, Henrique R, Bergman AM, Zwart W. Linder S, et al. Among authors: severson tm. Eur Urol. 2023 Nov;84(5):455-460. doi: 10.1016/j.eururo.2023.05.032. Epub 2023 Jun 2. Eur Urol. 2023. PMID: 37271632
PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription.
Mayayo-Peralta I, Gregoricchio S, Schuurman K, Yavuz S, Zaalberg A, Kojic A, Abbott N, Geverts B, Beerthuijzen S, Siefert J, Severson TM, van Baalen M, Hoekman L, Lieftink C, Altelaar M, Beijersbergen RL, Houtsmuller AB, Prekovic S, Zwart W. Mayayo-Peralta I, et al. Among authors: severson tm. Nucleic Acids Res. 2023 Oct 13;51(18):9576-9593. doi: 10.1093/nar/gkad267. Nucleic Acids Res. 2023. PMID: 37070193 Free PMC article.
Enhancer profiling identifies epigenetic markers of endocrine resistance and reveals therapeutic options for metastatic castration-resistant prostate cancer patients.
Severson TM, Zhu Y, Prekovic S, Schuurman K, Nguyen HM, Brown LG, Hakkola S, Kim Y, Kneppers J, Linder S, Stelloo S, Lieftink C, van der Heijden M, Nykter M, van der Noort V, Sanders J, Morris B, Jenster G, van Leenders GJ, Pomerantz M, Freedman ML, Beijersbergen RL, Urbanucci A, Wessels L, Corey E, Zwart W, Bergman AM. Severson TM, et al. medRxiv [Preprint]. 2023 Feb 24:2023.02.24.23286403. doi: 10.1101/2023.02.24.23286403. medRxiv. 2023. PMID: 36865297 Free PMC article. Preprint.
Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential.
Kneppers J, Severson TM, Siefert JC, Schol P, Joosten SEP, Yu IPL, Huang CF, Morova T, Altıntaş UB, Giambartolomei C, Seo JH, Baca SC, Carneiro I, Emberly E, Pasaniuc B, Jerónimo C, Henrique R, Freedman ML, Wessels LFA, Lack NA, Bergman AM, Zwart W. Kneppers J, et al. Among authors: severson tm. Nat Commun. 2022 Nov 30;13(1):7367. doi: 10.1038/s41467-022-35135-2. Nat Commun. 2022. PMID: 36450752 Free PMC article.
Double-strand break toxicity is chromatin context independent.
Friskes A, Koob L, Krenning L, Severson TM, Koeleman ES, Vergara X, Schubert M, van den Berg J, Evers B, Manjón AG, Joosten S, Kim Y, Zwart W, Medema RH. Friskes A, et al. Among authors: severson tm. Nucleic Acids Res. 2022 Sep 23;50(17):9930-9947. doi: 10.1093/nar/gkac758. Nucleic Acids Res. 2022. PMID: 36107780 Free PMC article.
69 results