Major LL - Search Results

1

A structural perspective on the enzymes that convert dTDP-d-glucose into dTDP-l-rhamnose.

Dong C, Beis K, Giraud MF, Blankenfeldt W, Allard S, Major LL, Kerr ID, Whitfield C, Naismith JH. Dong C, et al. Among authors: major ll. Biochem Soc Trans. 2003 Jun;31(Pt 3):532-6. doi: 10.1042/bst0310532. Biochem Soc Trans. 2003. PMID: 12773151 Review.

2

High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme.

Dong C, Major LL, Allen A, Blankenfeldt W, Maskell D, Naismith JH. Dong C, et al. Among authors: major ll. Structure. 2003 Jun;11(6):715-23. doi: 10.1016/s0969-2126(03)00098-4. Structure. 2003. PMID: 12791259 Free article.

3

The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme.

Merkel AB, Major LL, Errey JC, Burkart MD, Field RA, Walsh CT, Naismith JH. Merkel AB, et al. Among authors: major ll. J Biol Chem. 2004 Jul 30;279(31):32684-91. doi: 10.1074/jbc.M404091200. Epub 2004 May 24. J Biol Chem. 2004. PMID: 15159413 Free article.

4

Structure and function of GDP-mannose-3',5'-epimerase: an enzyme which performs three chemical reactions at the same active site.

Major LL, Wolucka BA, Naismith JH. Major LL, et al. J Am Chem Soc. 2005 Dec 28;127(51):18309-20. doi: 10.1021/ja056490i. J Am Chem Soc. 2005. PMID: 16366586 Free PMC article.

5

RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation.

Dong C, Major LL, Srikannathasan V, Errey JC, Giraud MF, Lam JS, Graninger M, Messner P, McNeil MR, Field RA, Whitfield C, Naismith JH. Dong C, et al. Among authors: major ll. J Mol Biol. 2007 Jan 5;365(1):146-59. doi: 10.1016/j.jmb.2006.09.063. Epub 2006 Sep 29. J Mol Biol. 2007. PMID: 17046787 Free PMC article.

6

Screening the MayBridge Rule of 3 Fragment Library for Compounds That Interact with the Trypanosoma brucei myo-Inositol-3-Phosphate Synthase and/or Show Trypanocidal Activity.

Major LL, Smith TK. Major LL, et al. Mol Biol Int. 2011;2011:389364. doi: 10.4061/2011/389364. Epub 2011 May 17. Mol Biol Int. 2011. PMID: 22091402 Free PMC article.

7

The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei.

Lilley AC, Major L, Young S, Stark MJ, Smith TK. Lilley AC, et al. Mol Microbiol. 2014 May;92(3):453-70. doi: 10.1111/mmi.12553. Epub 2014 Mar 28. Mol Microbiol. 2014. PMID: 24533860 Free PMC article.

8

Novel Benzothiazole-based Ureas as 17β-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment.

Aitken L, Benek O, McKelvie BE, Hughes RE, Hroch L, Schmidt M, Major LL, Vinklarova L, Kuca K, Smith TK, Musilek K, Gunn-Moore FJ. Aitken L, et al. Among authors: major ll. Molecules. 2019 Jul 29;24(15):2757. doi: 10.3390/molecules24152757. Molecules. 2019. PMID: 31362457 Free PMC article.

9

Lipidomic analysis of bloodstream and procyclic form Trypanosoma brucei.

Richmond GS, Gibellini F, Young SA, Major L, Denton H, Lilley A, Smith TK. Richmond GS, et al. Parasitology. 2010 Aug;137(9):1357-92. doi: 10.1017/S0031182010000715. Parasitology. 2010. PMID: 20602846 Free PMC article. Review.

10

Synthesis and in vitro/in vivo evaluation of the antitrypanosomal activity of 3-bromoacivicin, a potent CTP synthetase inhibitor.

Conti P, Pinto A, Wong PE, Major LL, Tamborini L, Iannuzzi MC, De Micheli C, Barrett MP, Smith TK. Conti P, et al. Among authors: major ll. ChemMedChem. 2011 Feb 7;6(2):329-33. doi: 10.1002/cmdc.201000417. Epub 2010 Dec 22. ChemMedChem. 2011. PMID: 21275056 Free PMC article.

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