Hungate RW - Search Results

1

Discovery and evaluation of 3-(5-thien-3-ylpyridin-3-yl)-1H-indoles as a novel class of KDR kinase inhibitors.

Fraley ME, Arrington KL, Hambaugh SR, Hoffman WF, Cunningham AM, Young MB, Hungate RW, Tebben AJ, Rutledge RZ, Kendall RL, Huckle WR, McFall RC, Coll KE, Thomas KA. Fraley ME, et al. Among authors: hungate rw. Bioorg Med Chem Lett. 2003 Sep 15;13(18):2973-6. doi: 10.1016/s0960-894x(03)00627-9. Bioorg Med Chem Lett. 2003. PMID: 12941314

2

Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: a new class of KDR kinase inhibitors.

Fraley ME, Hoffman WF, Rubino RS, Hungate RW, Tebben AJ, Rutledge RZ, McFall RC, Huckle WR, Kendall RL, Coll KE, Thomas KA. Fraley ME, et al. Among authors: hungate rw. Bioorg Med Chem Lett. 2002 Oct 7;12(19):2767-70. doi: 10.1016/s0960-894x(02)00525-5. Bioorg Med Chem Lett. 2002. PMID: 12217372

3

Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics.

Fraley ME, Rubino RS, Hoffman WF, Hambaugh SR, Arrington KL, Hungate RW, Bilodeau MT, Tebben AJ, Rutledge RZ, Kendall RL, McFall RC, Huckle WR, Coll KE, Thomas KA. Fraley ME, et al. Among authors: hungate rw. Bioorg Med Chem Lett. 2002 Dec 16;12(24):3537-41. doi: 10.1016/s0960-894x(02)00827-2. Bioorg Med Chem Lett. 2002. PMID: 12443771

4

Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR.

Bilodeau MT, Cunningham AM, Koester TJ, Ciecko PA, Coll KE, Huckle WR, Hungate RW, Kendall RL, McFall RC, Mao X, Rutledge RZ, Thomas KA. Bilodeau MT, et al. Among authors: hungate rw. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2485-8. doi: 10.1016/s0960-894x(03)00485-2. Bioorg Med Chem Lett. 2003. PMID: 12852948

5

The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase.

Bilodeau MT, Rodman LD, McGaughey GB, Coll KE, Koester TJ, Hoffman WF, Hungate RW, Kendall RL, McFall RC, Rickert KW, Rutledge RZ, Thomas KA. Bilodeau MT, et al. Among authors: hungate rw. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2941-5. doi: 10.1016/j.bmcl.2004.03.052. Bioorg Med Chem Lett. 2004. PMID: 15125964

6

Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation.

Tegley CM, Viswanadhan VN, Biswas K, Frohn MJ, Peterkin TA, Chang C, Bürli RW, Dao JH, Veith H, Rogers N, Yoder SC, Biddlecome G, Tagari P, Allen JR, Hungate RW. Tegley CM, et al. Among authors: hungate rw. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3925-8. doi: 10.1016/j.bmcl.2008.06.031. Epub 2008 Jun 13. Bioorg Med Chem Lett. 2008. PMID: 18579373

7

Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseases.

Chen N, Bürli RW, Neira S, Hungate R, Zhang D, Yu V, Nguyen Y, Tudor Y, Plant M, Flynn S, Meagher KL, Lee MR, Zhang X, Itano A, Schrag M, Xu Y, Ng GY, Hu E. Chen N, et al. Among authors: hungate r. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4137-41. doi: 10.1016/j.bmcl.2008.05.089. Epub 2008 May 28. Bioorg Med Chem Lett. 2008. PMID: 18554909

8

Discovery of amido-benzisoxazoles as potent c-Kit inhibitors.

Kunz RK, Rumfelt S, Chen N, Zhang D, Tasker AS, Bürli R, Hungate R, Yu V, Nguyen Y, Whittington DA, Meagher KL, Plant M, Tudor Y, Schrag M, Xu Y, Ng GY, Hu E. Kunz RK, et al. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5115-7. doi: 10.1016/j.bmcl.2008.07.111. Epub 2008 Jul 31. Bioorg Med Chem Lett. 2008. PMID: 18723346

9

Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit.

Hu E, Tasker A, White RD, Kunz RK, Human J, Chen N, Bürli R, Hungate R, Novak P, Itano A, Zhang X, Yu V, Nguyen Y, Tudor Y, Plant M, Flynn S, Xu Y, Meagher KL, Whittington DA, Ng GY. Hu E, et al. J Med Chem. 2008 Jun 12;51(11):3065-8. doi: 10.1021/jm800188g. Epub 2008 May 1. J Med Chem. 2008. PMID: 18447379

10

Design, synthesis, and biological evaluation of potent c-Met inhibitors.

D'Angelo ND, Bellon SF, Booker SK, Cheng Y, Coxon A, Dominguez C, Fellows I, Hoffman D, Hungate R, Kaplan-Lefko P, Lee MR, Li C, Liu L, Rainbeau E, Reider PJ, Rex K, Siegmund A, Sun Y, Tasker AS, Xi N, Xu S, Yang Y, Zhang Y, Burgess TL, Dussault I, Kim TS. D'Angelo ND, et al. J Med Chem. 2008 Sep 25;51(18):5766-79. doi: 10.1021/jm8006189. J Med Chem. 2008. PMID: 18763753

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