Varshavsky A - Search Results

1

Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway.

Kwon YT, Xia Z, An JY, Tasaki T, Davydov IV, Seo JW, Sheng J, Xie Y, Varshavsky A. Kwon YT, et al. Among authors: varshavsky a. Mol Cell Biol. 2003 Nov;23(22):8255-71. doi: 10.1128/MCB.23.22.8255-8271.2003. Mol Cell Biol. 2003. PMID: 14585983 Free PMC article.

2

A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.

Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, Muesing M, Kwon YT. Tasaki T, et al. Among authors: varshavsky a. Mol Cell Biol. 2005 Aug;25(16):7120-36. doi: 10.1128/MCB.25.16.7120-7136.2005. Mol Cell Biol. 2005. PMID: 16055722 Free PMC article.

3

Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.

An JY, Seo JW, Tasaki T, Lee MJ, Varshavsky A, Kwon YT. An JY, et al. Among authors: varshavsky a. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6212-7. doi: 10.1073/pnas.0601700103. Epub 2006 Apr 10. Proc Natl Acad Sci U S A. 2006. PMID: 16606826 Free PMC article.

4

Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.

Tasaki T, Sohr R, Xia Z, Hellweg R, Hörtnagl H, Varshavsky A, Kwon YT. Tasaki T, et al. Among authors: varshavsky a. J Biol Chem. 2007 Jun 22;282(25):18510-18520. doi: 10.1074/jbc.M701894200. Epub 2007 Apr 26. J Biol Chem. 2007. PMID: 17462990 Free article.

5

Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.

Kwon YT, Xia Z, Davydov IV, Lecker SH, Varshavsky A. Kwon YT, et al. Among authors: varshavsky a. Mol Cell Biol. 2001 Dec;21(23):8007-21. doi: 10.1128/MCB.21.23.8007-8021.2001. Mol Cell Biol. 2001. PMID: 11689692 Free PMC article.

6

RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.

Yin J, Kwon YT, Varshavsky A, Wang W. Yin J, et al. Among authors: varshavsky a. Hum Mol Genet. 2004 Oct 15;13(20):2421-30. doi: 10.1093/hmg/ddh269. Epub 2004 Aug 18. Hum Mol Genet. 2004. PMID: 15317757

7

Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway.

Kwon YT, Kashina AS, Varshavsky A. Kwon YT, et al. Among authors: varshavsky a. Mol Cell Biol. 1999 Jan;19(1):182-93. doi: 10.1128/MCB.19.1.182. Mol Cell Biol. 1999. PMID: 9858543 Free PMC article.

8

Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway.

Kwon YT, Balogh SA, Davydov IV, Kashina AS, Yoon JK, Xie Y, Gaur A, Hyde L, Denenberg VH, Varshavsky A. Kwon YT, et al. Among authors: varshavsky a. Mol Cell Biol. 2000 Jun;20(11):4135-48. doi: 10.1128/MCB.20.11.4135-4148.2000. Mol Cell Biol. 2000. PMID: 10805755 Free PMC article.

9

Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain.

Du F, Navarro-Garcia F, Xia Z, Tasaki T, Varshavsky A. Du F, et al. Among authors: varshavsky a. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14110-5. doi: 10.1073/pnas.172527399. Epub 2002 Oct 21. Proc Natl Acad Sci U S A. 2002. PMID: 12391316 Free PMC article.

10

UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis.

Xie Y, Varshavsky A. Xie Y, et al. Among authors: varshavsky a. Nat Cell Biol. 2002 Dec;4(12):1003-7. doi: 10.1038/ncb889. Nat Cell Biol. 2002. PMID: 12447385

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