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Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis.
Ibrahim AS, Bowman JC, Avanessian V, Brown K, Spellberg B, Edwards JE Jr, Douglas CM. Ibrahim AS, et al. Among authors: avanessian v. Antimicrob Agents Chemother. 2005 Feb;49(2):721-7. doi: 10.1128/AAC.49.2.721-727.2005. Antimicrob Agents Chemother. 2005. PMID: 15673756 Free PMC article.