Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice.
Lin J, Callender JA, Mayfield JE, McClatchy DB, Ojeda-Juárez D, Pourhamzeh M, Soldau K, Kurt TD, Danque GA, Khuu H, Ronson JE, Pizzo DP, Du Y, Gruber MA, Sevillano AM, Wang J, Orrú CD, Chen J, Funk G, Aguilar-Calvo P, Aulston BD, Roy S, Rho JM, Bui JD, Newton AC, Lipton SA, Caughey B, Patrick GN, Doré K, Yates JR 3rd, Sigurdson CJ.
Lin J, et al. Among authors: yates jr 3rd.
J Clin Invest. 2025 Apr 4;135(10):e186432. doi: 10.1172/JCI186432. eCollection 2025 May 15.
J Clin Invest. 2025.
PMID: 40185484
Free PMC article.