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The laminin-keratin link shields the nucleus from mechanical deformation and signalling.
Kechagia Z, Sáez P, Gómez-González M, Canales B, Viswanadha S, Zamarbide M, Andreu I, Koorman T, Beedle AEM, Elosegui-Artola A, Derksen PWB, Trepat X, Arroyo M, Roca-Cusachs P. Kechagia Z, et al. Nat Mater. 2023 Nov;22(11):1409-1420. doi: 10.1038/s41563-023-01657-3. Epub 2023 Sep 14. Nat Mater. 2023. PMID: 37709930 Free PMC article.
Modeling metastatic breast cancer in mice.
Jonkers J, Derksen PW. Jonkers J, et al. Among authors: derksen pw. J Mammary Gland Biol Neoplasia. 2007 Sep;12(2-3):191-203. doi: 10.1007/s10911-007-9050-8. J Mammary Gland Biol Neoplasia. 2007. PMID: 17587153 Free article. Review.
NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin.
Lehembre F, Yilmaz M, Wicki A, Schomber T, Strittmatter K, Ziegler D, Kren A, Went P, Derksen PW, Berns A, Jonkers J, Christofori G. Lehembre F, et al. Among authors: derksen pw. EMBO J. 2008 Oct 8;27(19):2603-15. doi: 10.1038/emboj.2008.178. Epub 2008 Sep 4. EMBO J. 2008. PMID: 18772882 Free PMC article.
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.
Rottenberg S, Jaspers JE, Kersbergen A, van der Burg E, Nygren AO, Zander SA, Derksen PW, de Bruin M, Zevenhoven J, Lau A, Boulter R, Cranston A, O'Connor MJ, Martin NM, Borst P, Jonkers J. Rottenberg S, et al. Among authors: derksen pw. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17079-84. doi: 10.1073/pnas.0806092105. Epub 2008 Oct 29. Proc Natl Acad Sci U S A. 2008. PMID: 18971340 Free PMC article.
84 results