Eigenbrot C - Search Results

1

Structural insight into distinct mechanisms of protease inhibition by antibodies.

Wu Y, Eigenbrot C, Liang WC, Stawicki S, Shia S, Fan B, Ganesan R, Lipari MT, Kirchhofer D. Wu Y, et al. Among authors: eigenbrot c. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19784-9. doi: 10.1073/pnas.0708251104. Epub 2007 Dec 5. Proc Natl Acad Sci U S A. 2007. PMID: 18077410 Free PMC article.

2

Cyclic RGD peptide analogues as antiplatelet antithrombotics.

Barker PL, Bullens S, Bunting S, Burdick DJ, Chan KS, Deisher T, Eigenbrot C, Gadek TR, Gantzos R, Lipari MT, et al. Barker PL, et al. Among authors: eigenbrot c. J Med Chem. 1992 May 29;35(11):2040-8. doi: 10.1021/jm00089a014. J Med Chem. 1992. PMID: 1597855

3

Peptide exosite inhibitors of factor VIIa as anticoagulants.

Dennis MS, Eigenbrot C, Skelton NJ, Ultsch MH, Santell L, Dwyer MA, O'Connell MP, Lazarus RA. Dennis MS, et al. Among authors: eigenbrot c. Nature. 2000 Mar 30;404(6777):465-70. doi: 10.1038/35006574. Nature. 2000. PMID: 10761907

4

The tissue factor region that interacts with substrates factor IX and Factor X.

Kirchhofer D, Lipari MT, Moran P, Eigenbrot C, Kelley RF. Kirchhofer D, et al. Among authors: eigenbrot c. Biochemistry. 2000 Jun 27;39(25):7380-7. doi: 10.1021/bi000182+. Biochemistry. 2000. PMID: 10858285

5

Epitope location on tissue factor determines the anticoagulant potency of monoclonal anti-tissue factor antibodies.

Kirchhofer D, Moran P, Chiang N, Kim J, Riederer MA, Eigenbrot C, Kelley RF. Kirchhofer D, et al. Among authors: eigenbrot c. Thromb Haemost. 2000 Dec;84(6):1072-81. Thromb Haemost. 2000. PMID: 11154116

6

The tissue factor region that interacts with factor Xa in the activation of factor VII.

Kirchhofer D, Eigenbrot C, Lipari MT, Moran P, Peek M, Kelley RF. Kirchhofer D, et al. Among authors: eigenbrot c. Biochemistry. 2001 Jan 23;40(3):675-82. doi: 10.1021/bi002013v. Biochemistry. 2001. PMID: 11170384

7

The factor VII zymogen structure reveals reregistration of beta strands during activation.

Eigenbrot C, Kirchhofer D, Dennis MS, Santell L, Lazarus RA, Stamos J, Ultsch MH. Eigenbrot C, et al. Structure. 2001 Jul 3;9(7):627-36. doi: 10.1016/s0969-2126(01)00624-4. Structure. 2001. PMID: 11470437 Free article.

8

New insight into how tissue factor allosterically regulates factor VIIa.

Eigenbrot C, Kirchhofer D. Eigenbrot C, et al. Trends Cardiovasc Med. 2002 Jan;12(1):19-26. doi: 10.1016/s1050-1738(01)00139-6. Trends Cardiovasc Med. 2002. PMID: 11796240 Review.

9

Engineering exosite peptides for complete inhibition of factor VIIa using a protease switch with substrate phage.

Maun HR, Eigenbrot C, Lazarus RA. Maun HR, et al. Among authors: eigenbrot c. J Biol Chem. 2003 Jun 13;278(24):21823-30. doi: 10.1074/jbc.M300951200. Epub 2003 Mar 25. J Biol Chem. 2003. PMID: 12657647 Free article.

Limitations of current anticoagulant therapies have led us to develop two distinct classes of exosite peptide inhibitors for the initiator of the clotting process, the tissue factor-factor VIIa (TF.FVIIa) complex (Roberge, M., Santell, L., Dennis, M. S., Eigenbrot, C …

Limitations of current anticoagulant therapies have led us to develop two distinct classes of exosite peptide inhibitors for the initiator o …

10

Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1.

Kirchhofer D, Peek M, Li W, Stamos J, Eigenbrot C, Kadkhodayan S, Elliott JM, Corpuz RT, Lazarus RA, Moran P. Kirchhofer D, et al. Among authors: eigenbrot c. J Biol Chem. 2003 Sep 19;278(38):36341-9. doi: 10.1074/jbc.M304643200. Epub 2003 Jun 18. J Biol Chem. 2003. PMID: 12815039 Free article.

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