Lever JR - Search Results

1

Phorbol ester induced trafficking-independent regulation and enhanced phosphorylation of the dopamine transporter associated with membrane rafts and cholesterol.

Foster JD, Adkins SD, Lever JR, Vaughan RA. Foster JD, et al. Among authors: lever jr. J Neurochem. 2008 Jun;105(5):1683-99. doi: 10.1111/j.1471-4159.2008.05262.x. Epub 2008 Feb 1. J Neurochem. 2008. PMID: 18248623 Free PMC article.

2

Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter.

Vaughan RA, Sakrikar DS, Parnas ML, Adkins S, Foster JD, Duval RA, Lever JR, Kulkarni SS, Hauck-Newman A. Vaughan RA, et al. Among authors: lever jr. J Biol Chem. 2007 Mar 23;282(12):8915-25. doi: 10.1074/jbc.M610633200. Epub 2007 Jan 25. J Biol Chem. 2007. PMID: 17255098 Free article.

3

Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.

Dahal RA, Pramod AB, Sharma B, Krout D, Foster JD, Cha JH, Cao J, Newman AH, Lever JR, Vaughan RA, Henry LK. Dahal RA, et al. Among authors: lever jr. J Biol Chem. 2014 Oct 24;289(43):29712-27. doi: 10.1074/jbc.M114.571521. Epub 2014 Aug 31. J Biol Chem. 2014. PMID: 25179220 Free PMC article.

4

Identification of the benztropine analog [¹²⁵I]GA II 34 binding site on the human dopamine transporter.

Tomlinson MJ, Krout D, Pramod AB, Lever JR, Newman AH, Henry LK, Vaughan RA. Tomlinson MJ, et al. Among authors: lever jr. Neurochem Int. 2019 Feb;123:34-45. doi: 10.1016/j.neuint.2018.08.008. Epub 2018 Aug 17. Neurochem Int. 2019. PMID: 30125594 Free PMC article.

5

Labeling of dopamine transporter transmembrane domain 1 with the tropane ligand N-[4-(4-azido-3-[125I]iodophenyl)butyl]-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane implicates proximity of cocaine and substrate active sites.

Parnas ML, Gaffaney JD, Zou MF, Lever JR, Newman AH, Vaughan RA. Parnas ML, et al. Among authors: lever jr. Mol Pharmacol. 2008 Apr;73(4):1141-50. doi: 10.1124/mol.107.043679. Epub 2008 Jan 23. Mol Pharmacol. 2008. PMID: 18216182

6

A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone.

Lapinsky DJ, Aggarwal S, Huang Y, Surratt CK, Lever JR, Foster JD, Vaughan RA. Lapinsky DJ, et al. Among authors: lever jr. Bioorg Med Chem. 2009 Jun 1;17(11):3770-4. doi: 10.1016/j.bmc.2009.04.057. Epub 2009 May 3. Bioorg Med Chem. 2009. PMID: 19442525 Free PMC article.

7

Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi-site molecular tethering of photoactive cocaine analogs.

Krout D, Pramod AB, Dahal RA, Tomlinson MJ, Sharma B, Foster JD, Zou MF, Boatang C, Newman AH, Lever JR, Vaughan RA, Henry LK. Krout D, et al. Among authors: lever jr. Biochem Pharmacol. 2017 Oct 15;142:204-215. doi: 10.1016/j.bcp.2017.07.015. Epub 2017 Jul 19. Biochem Pharmacol. 2017. PMID: 28734777 Free PMC article.

8

Dual incorporation of photoaffinity ligands on dopamine transporters implicates proximity of labeled domains.

Vaughan RA, Gaffaney JD, Lever JR, Reith ME, Dutta AK. Vaughan RA, et al. Among authors: lever jr. Mol Pharmacol. 2001 May;59(5):1157-64. doi: 10.1124/mol.59.5.1157. Mol Pharmacol. 2001. PMID: 11306699

9

Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling.

Lapinsky DJ, Velagaleti R, Yarravarapu N, Liu Y, Huang Y, Surratt CK, Lever JR, Foster JD, Acharya R, Vaughan RA, Deutsch HM. Lapinsky DJ, et al. Among authors: lever jr. Bioorg Med Chem. 2011 Jan 1;19(1):504-12. doi: 10.1016/j.bmc.2010.11.002. Epub 2010 Nov 4. Bioorg Med Chem. 2011. PMID: 21129986 Free PMC article.

10

Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram.

Kumar V, Yarravarapu N, Lapinsky DJ, Perley D, Felts B, Tomlinson MJ, Vaughan RA, Henry LK, Lever JR, Newman AH. Kumar V, et al. Among authors: lever jr. J Med Chem. 2015 Jul 23;58(14):5609-19. doi: 10.1021/acs.jmedchem.5b00682. Epub 2015 Jul 8. J Med Chem. 2015. PMID: 26153715 Free PMC article.

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