Spruce LW - Search Results

1

Novel heteroarotinoids: synthesis and biological activity.

Spruce LW, Gale JB, Berlin KD, Verma AK, Breitman TR, Ji XH, van der Helm D. Spruce LW, et al. J Med Chem. 1991 Jan;34(1):430-9. doi: 10.1021/jm00105a065. J Med Chem. 1991. PMID: 1992144

2

Heteroarotinoids. Synthesis, characterization, and biological activity in terms of an assessment of these systems to inhibit the induction of ornithine decarboxylase activity and to induce terminal differentiation of HL-60 cells.

Spruce LW, Rajadhyaksha SN, Berlin KD, Gale JB, Miranda ET, Ford WT, Blossey EC, Verma AK, Hossain MB, van der Helm D, et al. Spruce LW, et al. J Med Chem. 1987 Aug;30(8):1474-82. doi: 10.1021/jm00391a033. J Med Chem. 1987. PMID: 3612691

3

Biologically active heteroarotinoids exhibiting anticancer activity and decreased toxicity.

Benbrook DM, Madler MM, Spruce LW, Birckbichler PJ, Nelson EC, Subramanian S, Weerasekare GM, Gale JB, Patterson MK Jr, Wang B, Wang W, Lu S, Rowland TC, DiSivestro P, Lindamood C 3rd, Hill DL, Berlin KD. Benbrook DM, et al. Among authors: spruce lw. J Med Chem. 1997 Oct 24;40(22):3567-83. doi: 10.1021/jm970196m. J Med Chem. 1997. PMID: 9357524

4

Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase.

Ohmoto K, Yamamoto T, Horiuchi T, Imanishi H, Odagaki Y, Kawabata K, Sekioka T, Hirota Y, Matsuoka S, Nakai H, Toda M, Cheronis JC, Spruce LW, Gyorkos A, Wieczorek M. Ohmoto K, et al. Among authors: spruce lw. J Med Chem. 2000 Dec 28;43(26):4927-9. doi: 10.1021/jm0004087. J Med Chem. 2000. PMID: 11150162 No abstract available.

5

Development of orally active nonpeptidic inhibitors of human neutrophil elastase.

Ohmoto K, Yamamoto T, Okuma M, Horiuchi T, Imanishi H, Odagaki Y, Kawabata K, Sekioka T, Hirota Y, Matsuoka S, Nakai H, Toda M, Cheronis JC, Spruce LW, Gyorkos A, Wieczorek M. Ohmoto K, et al. Among authors: spruce lw. J Med Chem. 2001 Apr 12;44(8):1268-85. doi: 10.1021/jm000410y. J Med Chem. 2001. PMID: 11312926

6

Synthesis and characterization of human neutrophil elastase inhibitors derived from aromatic esters of phenylalkanoic acids.

Kirschenheuter GP, Oleksyszyn J, Spruce LW, Wieczorek M, Kloppel TM, Simon SR, Cheronis JC. Kirschenheuter GP, et al. Among authors: spruce lw. Agents Actions Suppl. 1993;42:71-82. doi: 10.1007/978-3-0348-7397-0_6. Agents Actions Suppl. 1993. PMID: 8356932 No abstract available.

7

Biochemical characterization of alpha-ketooxadiazole inhibitors of elastases.

Wieczorek M, Gyorkos A, Spruce LW, Ettinger A, Ross SE, Kroona HS, Burgos-Lepley CE, Bratton LD, Drennan TS, Garnert DL, Von Burg G, Pilkington CG, Cheronis JC. Wieczorek M, et al. Among authors: spruce lw. Arch Biochem Biophys. 1999 Jul 15;367(2):193-201. doi: 10.1006/abbi.1999.1249. Arch Biochem Biophys. 1999. PMID: 10395735

8

Bradykinin antagonists in human systems: correlation between receptor binding, calcium signalling in isolated cells, and functional activity in isolated ileum.

Wieczorek M, Pilyavskaya A, Burkard M, Zuzack JS, Jones SW, Francis MD, Beckey VE, Ross SE, Goodfellow VS, Fitzpatrick TD, Marathe MV, Gyorkos A, Spruce LW, Selig WM, Stewart JM, Gera L, Whalley ET. Wieczorek M, et al. Among authors: spruce lw. Biochem Pharmacol. 1997 Jul 15;54(2):283-91. doi: 10.1016/s0006-2952(97)00186-x. Biochem Pharmacol. 1997. PMID: 9271333

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