Johnson AP - Search Results

1

A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH.

Cowen D, Bedingfield P, McConkey GA, Fishwick CW, Johnson AP. Cowen D, et al. Among authors: johnson ap. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1284-7. doi: 10.1016/j.bmcl.2009.11.079. Epub 2009 Nov 27. Bioorg Med Chem Lett. 2010. PMID: 20034791

2

Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme MurD.

Horton JR, Bostock JM, Chopra I, Hesse L, Phillips SE, Adams DJ, Johnson AP, Fishwick CW. Horton JR, et al. Among authors: johnson ap. Bioorg Med Chem Lett. 2003 May 5;13(9):1557-60. doi: 10.1016/s0960-894x(03)00176-8. Bioorg Med Chem Lett. 2003. PMID: 12699754

3

The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

Heikkilä T, Thirumalairajan S, Davies M, Parsons MR, McConkey AG, Fishwick CW, Johnson AP. Heikkilä T, et al. Among authors: johnson ap. Bioorg Med Chem Lett. 2006 Jan 1;16(1):88-92. doi: 10.1016/j.bmcl.2005.09.045. Epub 2005 Oct 19. Bioorg Med Chem Lett. 2006. PMID: 16236496

4

Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.

Heikkilä T, Ramsey C, Davies M, Galtier C, Stead AM, Johnson AP, Fishwick CW, Boa AN, McConkey GA. Heikkilä T, et al. Among authors: johnson ap. J Med Chem. 2007 Jan 25;50(2):186-91. doi: 10.1021/jm060687j. J Med Chem. 2007. PMID: 17228860

5

Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.

Davies M, Heikkilä T, McConkey GA, Fishwick CW, Parsons MR, Johnson AP. Davies M, et al. Among authors: johnson ap. J Med Chem. 2009 May 14;52(9):2683-93. doi: 10.1021/jm800963t. J Med Chem. 2009. PMID: 19351152

6

Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening.

Yi Mok N, Chadwick J, Kellett KA, Hooper NM, Johnson AP, Fishwick CW. Yi Mok N, et al. Among authors: johnson ap. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6770-4. doi: 10.1016/j.bmcl.2009.09.103. Epub 2009 Oct 2. Bioorg Med Chem Lett. 2009. PMID: 19854048

7

Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases.

Bedingfield PT, Cowen D, Acklam P, Cunningham F, Parsons MR, McConkey GA, Fishwick CW, Johnson AP. Bedingfield PT, et al. Among authors: johnson ap. J Med Chem. 2012 Jun 28;55(12):5841-50. doi: 10.1021/jm300157n. Epub 2012 Jun 15. J Med Chem. 2012. PMID: 22621375

8

Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design.

Mok NY, Chadwick J, Kellett KA, Casas-Arce E, Hooper NM, Johnson AP, Fishwick CW. Mok NY, et al. Among authors: johnson ap. J Med Chem. 2013 Mar 14;56(5):1843-52. doi: 10.1021/jm301127x. Epub 2013 Feb 22. J Med Chem. 2013. PMID: 23374014 Free article.

9

An in silico structure-based approach to anti-infective drug discovery.

Cunningham F, McPhillie MJ, Johnson AP, Fishwick CW. Cunningham F, et al. Among authors: johnson ap. Parasitology. 2014 Jan;141(1):17-27. doi: 10.1017/S0031182013000693. Epub 2013 Jun 17. Parasitology. 2014. PMID: 23768800 Review.

10

Structure-based ligand design of novel bacterial RNA polymerase inhibitors.

McPhillie MJ, Trowbridge R, Mariner KR, O'Neill AJ, Johnson AP, Chopra I, Fishwick CW. McPhillie MJ, et al. Among authors: johnson ap. ACS Med Chem Lett. 2011 Jul 29;2(10):729-34. doi: 10.1021/ml200087m. eCollection 2011 Oct 13. ACS Med Chem Lett. 2011. PMID: 24900260 Free PMC article.

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