Velázquez CA - Search Results

1

Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.

Chowdhury MA, Abdellatif KR, Dong Y, Yu G, Huang Z, Rahman M, Das D, Velázquez CA, Suresh MR, Knaus EE. Chowdhury MA, et al. Among authors: velazquez ca. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1324-9. doi: 10.1016/j.bmcl.2010.01.014. Epub 2010 Jan 11. Bioorg Med Chem Lett. 2010. PMID: 20097072

2

Syntheses, calcium channel agonist-antagonist modulation activities, and nitric oxide release studies of nitrooxyalkyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2,1,3-benzoxadiazol-4-yl)pyridine-5-carboxylate racemates, enantiomers, and diastereomers.

Shan R, Velazquez C, Knaus EE. Shan R, et al. J Med Chem. 2004 Jan 1;47(1):254-61. doi: 10.1021/jm030333h. J Med Chem. 2004. PMID: 14695839

3

Synthesis and biological evaluation of 1,4-dihydropyridine calcium channel modulators having a diazen-1-ium-1,2-diolate nitric oxide donor moiety for the potential treatment of congestive heart failure.

Velázquez C, Knaus EE. Velázquez C, et al. Bioorg Med Chem. 2004 Jul 15;12(14):3831-40. doi: 10.1016/j.bmc.2004.05.008. Bioorg Med Chem. 2004. PMID: 15210150

4

Hantzsch 1,4-dihydropyridines containing a diazen-1-ium-1,2-diolate nitric oxide donor moiety to study calcium channel antagonist structure-activity relationships and nitric oxide release.

Nguyen JT, Velázquez CA, Knaus EE. Nguyen JT, et al. Among authors: velazquez ca. Bioorg Med Chem. 2005 Mar 1;13(5):1725-38. doi: 10.1016/j.bmc.2004.12.002. Bioorg Med Chem. 2005. PMID: 15698790

5

Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents.

Velázquez C, Rao PN, McDonald R, Knaus EE. Velázquez C, et al. Bioorg Med Chem. 2005 Apr 15;13(8):2749-57. doi: 10.1016/j.bmc.2005.02.034. Bioorg Med Chem. 2005. PMID: 15781386

6

Design and synthesis of alkyl 7,7-dihalo-3-methyl-5-(nitrophenyl)-2-azabicyclo[4.1.0]hept-3-ene-4-carboxylates with calcium channel antagonist activity.

Mojarrad JS, Vo D, Velázquez C, Knaus EE. Mojarrad JS, et al. Bioorg Med Chem. 2005 Jun 2;13(12):4085-91. doi: 10.1016/j.bmc.2005.03.047. Bioorg Med Chem. 2005. PMID: 15911322

7

Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.

Velázquez C, Praveen Rao PN, Knaus EE. Velázquez C, et al. J Med Chem. 2005 Jun 16;48(12):4061-7. doi: 10.1021/jm050211k. J Med Chem. 2005. PMID: 15943479

8

O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.

Velázquez CA, Praveen Rao PN, Citro ML, Keefer LK, Knaus EE. Velázquez CA, et al. Bioorg Med Chem. 2007 Jul 15;15(14):4767-74. doi: 10.1016/j.bmc.2007.05.009. Epub 2007 May 6. Bioorg Med Chem. 2007. PMID: 17509888 Free PMC article.

9

Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies.

Velázquez CA, Chen QH, Citro ML, Keefer LK, Knaus EE. Velázquez CA, et al. J Med Chem. 2008 Mar 27;51(6):1954-61. doi: 10.1021/jm701450q. Epub 2008 Feb 29. J Med Chem. 2008. PMID: 18314945

10

Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.

Abdellatif KR, Chowdhury MA, Dong Y, Velázquez C, Das D, Suresh MR, Knaus EE. Abdellatif KR, et al. Bioorg Med Chem. 2008 Nov 15;16(22):9694-8. doi: 10.1016/j.bmc.2008.10.001. Epub 2008 Oct 5. Bioorg Med Chem. 2008. PMID: 18930406

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