Schlessinger J - Search Results

1

Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening.

Ravindranathan KP, Mandiyan V, Ekkati AR, Bae JH, Schlessinger J, Jorgensen WL. Ravindranathan KP, et al. Among authors: schlessinger j. J Med Chem. 2010 Feb 25;53(4):1662-72. doi: 10.1021/jm901386e. J Med Chem. 2010. PMID: 20121196 Free PMC article.

2

Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.

Lemmon MA, Ladbury JE, Mandiyan V, Zhou M, Schlessinger J. Lemmon MA, et al. Among authors: schlessinger j. J Biol Chem. 1994 Dec 16;269(50):31653-8. J Biol Chem. 1994. PMID: 7527391 Free article.

3

Thermodynamic studies of SHC phosphotyrosine interaction domain recognition of the NPXpY motif.

Mandiyan V, O'Brien R, Zhou M, Margolis B, Lemmon MA, Sturtevant JM, Schlessinger J. Mandiyan V, et al. Among authors: schlessinger j. J Biol Chem. 1996 Mar 1;271(9):4770-5. doi: 10.1074/jbc.271.9.4770. J Biol Chem. 1996. PMID: 8617744 Free article.

4

Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta.

Mandiyan V, Andreev J, Schlessinger J, Hubbard SR. Mandiyan V, et al. Among authors: schlessinger j. EMBO J. 1999 Dec 15;18(24):6890-8. doi: 10.1093/emboj/18.24.6890. EMBO J. 1999. PMID: 10601011 Free PMC article.

5

Cellular signaling by fibroblast growth factor receptors.

Eswarakumar VP, Lax I, Schlessinger J. Eswarakumar VP, et al. Among authors: schlessinger j. Cytokine Growth Factor Rev. 2005 Apr;16(2):139-49. doi: 10.1016/j.cytogfr.2005.01.001. Epub 2005 Feb 1. Cytokine Growth Factor Rev. 2005. PMID: 15863030 Review.

6

Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis.

Eswarakumar VP, Ozcan F, Lew ED, Bae JH, Tomé F, Booth CJ, Adams DJ, Lax I, Schlessinger J. Eswarakumar VP, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18603-8. doi: 10.1073/pnas.0609157103. Epub 2006 Nov 28. Proc Natl Acad Sci U S A. 2006. PMID: 17132737 Free PMC article.

7

Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3.

Eswarakumar VP, Schlessinger J. Eswarakumar VP, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3937-42. doi: 10.1073/pnas.0700012104. Epub 2007 Feb 23. Proc Natl Acad Sci U S A. 2007. PMID: 17360456 Free PMC article.

8

Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor.

Yuzawa S, Opatowsky Y, Zhang Z, Mandiyan V, Lax I, Schlessinger J. Yuzawa S, et al. Among authors: schlessinger j. Cell. 2007 Jul 27;130(2):323-34. doi: 10.1016/j.cell.2007.05.055. Cell. 2007. PMID: 17662946 Free article.

9

Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation.

Lew ED, Bae JH, Rohmann E, Wollnik B, Schlessinger J. Lew ED, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19802-7. doi: 10.1073/pnas.0709905104. Epub 2007 Dec 3. Proc Natl Acad Sci U S A. 2007. PMID: 18056630 Free PMC article.

10

The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations.

Lew ED, Furdui CM, Anderson KS, Schlessinger J. Lew ED, et al. Among authors: schlessinger j. Sci Signal. 2009 Feb 17;2(58):ra6. doi: 10.1126/scisignal.2000021. Sci Signal. 2009. PMID: 19224897 Free PMC article.

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