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Page 1
The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.
de Boer TP, Nalos L, Stary A, Kok B, Houtman MJ, Antoons G, van Veen TA, Beekman JD, de Groot BL, Opthof T, Rook MB, Vos MA, van der Heyden MA. de Boer TP, et al. Among authors: houtman mj. Br J Pharmacol. 2010 Apr;159(7):1532-41. doi: 10.1111/j.1476-5381.2010.00658.x. Epub 2010 Feb 24. Br J Pharmacol. 2010. PMID: 20180941 Free PMC article.
Reduction of fibrosis-related arrhythmias by chronic renin-angiotensin-aldosterone system inhibitors in an aged mouse model.
Stein M, Boulaksil M, Jansen JA, Herold E, Noorman M, Joles JA, van Veen TA, Houtman MJ, Engelen MA, Hauer RN, de Bakker JM, van Rijen HV. Stein M, et al. Among authors: houtman mj. Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H310-21. doi: 10.1152/ajpheart.01137.2009. Epub 2010 Apr 30. Am J Physiol Heart Circ Physiol. 2010. PMID: 20435847 Free article.
Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.
Oros A, Houtman MJ, Neco P, Gomez AM, Rajamani S, Oosterhoff P, Attevelt NJ, Beekman JD, van der Heyden MA, Ver Donck L, Belardinelli L, Richard S, Antoons G, Vos MA; CONTICA investigators. Oros A, et al. Among authors: houtman mj. Br J Pharmacol. 2010 Sep;161(1):162-75. doi: 10.1111/j.1476-5381.2010.00883.x. Br J Pharmacol. 2010. PMID: 20718748 Free PMC article.
Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity.
Boulaksil M, Jungschleger JG, Antoons G, Houtman MJ, de Boer TP, Wilders R, Beekman JD, Maessen JG, van der Hulst FF, van der Heyden MA, van Veen TA, van Rijen HV, de Bakker JM, Vos MA. Boulaksil M, et al. Among authors: houtman mj. Circ Arrhythm Electrophysiol. 2011 Aug;4(4):566-76. doi: 10.1161/CIRCEP.110.958991. Epub 2011 May 27. Circ Arrhythm Electrophysiol. 2011. PMID: 21622813
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.
Nalos L, Varkevisser R, Jonsson MK, Houtman MJ, Beekman JD, van der Nagel R, Thomsen MB, Duker G, Sartipy P, de Boer TP, Peschar M, Rook MB, van Veen TA, van der Heyden MA, Vos MA. Nalos L, et al. Among authors: houtman mj. Br J Pharmacol. 2012 Jan;165(2):467-78. doi: 10.1111/j.1476-5381.2011.01558.x. Br J Pharmacol. 2012. PMID: 21718297 Free PMC article.
33 results