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The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.
de Boer TP, Nalos L, Stary A, Kok B, Houtman MJ, Antoons G, van Veen TA, Beekman JD, de Groot BL, Opthof T, Rook MB, Vos MA, van der Heyden MA. de Boer TP, et al. Among authors: kok b. Br J Pharmacol. 2010 Apr;159(7):1532-41. doi: 10.1111/j.1476-5381.2010.00658.x. Epub 2010 Feb 24. Br J Pharmacol. 2010. PMID: 20180941 Free PMC article.
Insights in KIR2.1 channel structure and function by an evolutionary approach; cloning and functional characterization of the first reptilian inward rectifier channel KIR2.1, derived from the California kingsnake (Lampropeltis getula californiae).
Houtman MJ, Korte SM, Ji Y, Kok B, Vos MA, Stary-Weinzinger A, van der Heyden MA. Houtman MJ, et al. Among authors: kok b. Biochem Biophys Res Commun. 2014 Oct 3;452(4):992-7. doi: 10.1016/j.bbrc.2014.09.031. Epub 2014 Sep 16. Biochem Biophys Res Commun. 2014. PMID: 25223803
Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent.
Takanari H, Bourgonje VJ, Fontes MS, Raaijmakers AJ, Driessen H, Jansen JA, van der Nagel R, Kok B, van Stuijvenberg L, Boulaksil M, Takemoto Y, Yamazaki M, Tsuji Y, Honjo H, Kamiya K, Kodama I, Anderson ME, van der Heyden MA, van Rijen HV, van Veen TA, Vos MA. Takanari H, et al. Among authors: kok b. Cardiovasc Res. 2016 Sep;111(4):410-21. doi: 10.1093/cvr/cvw173. Epub 2016 Jun 29. Cardiovasc Res. 2016. PMID: 27357638 Free PMC article.
252 results