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Disease progression strikingly differs in research and real-world Parkinson's populations.
Beaulieu-Jones BK, Frau F, Bozzi S, Chandross KJ, Peterschmitt MJ, Cohen C, Coulovrat C, Kumar D, Kruger MJ, Lipnick SL, Fitzsimmons L, Kohane IS, Scherzer CR. Beaulieu-Jones BK, et al. Among authors: scherzer cr. NPJ Parkinsons Dis. 2024 Mar 13;10(1):58. doi: 10.1038/s41531-024-00667-5. NPJ Parkinsons Dis. 2024. PMID: 38480700 Free PMC article.
Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.
Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson GA, Pitstick R, Peskind ER, Raskind MA, Li G, Montine TJ, Frosch MP, Hyman BT. Takeda S, et al. Among authors: scherzer cr. Ann Neurol. 2016 Sep;80(3):355-67. doi: 10.1002/ana.24716. Epub 2016 Aug 3. Ann Neurol. 2016. PMID: 27351289 Free PMC article.
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, Tyynelä J, Scherzer CR, Feany MB. Khurana V, et al. Among authors: scherzer cr. PLoS Genet. 2010 Jul 15;6(7):e1001026. doi: 10.1371/journal.pgen.1001026. PLoS Genet. 2010. PMID: 20664788 Free PMC article.
Molecular markers of early Parkinson's disease based on gene expression in blood.
Scherzer CR, Eklund AC, Morse LJ, Liao Z, Locascio JJ, Fefer D, Schwarzschild MA, Schlossmacher MG, Hauser MA, Vance JM, Sudarsky LR, Standaert DG, Growdon JH, Jensen RV, Gullans SR. Scherzer CR, et al. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):955-60. doi: 10.1073/pnas.0610204104. Epub 2007 Jan 10. Proc Natl Acad Sci U S A. 2007. PMID: 17215369 Free PMC article.
PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.
Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR; Global PD Gene Expression (GPEX) Consortium. Zheng B, et al. Among authors: scherzer cr. Sci Transl Med. 2010 Oct 6;2(52):52ra73. doi: 10.1126/scitranslmed.3001059. Sci Transl Med. 2010. PMID: 20926834 Free PMC article.
119 results