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Peptides derived from the CDR3-homologous domain of the CD4 molecule are specific inhibitors of HIV-1 and SIV infection, virus-induced cell fusion, and postinfection viral transmission in vitro. Implications for the design of small peptide anti-HIV therapeutic agents.
Rausch DM, Hwang KM, Padgett M, Voltz AH, Rivas A, Engleman E, Gaston I, McGrath M, Fraser B, Kalyanaraman VS, et al. Rausch DM, et al. Among authors: fraser b. Ann N Y Acad Sci. 1990;616:125-48. doi: 10.1111/j.1749-6632.1990.tb17834.x. Ann N Y Acad Sci. 1990. PMID: 2078014 Review.
Oil in the forest.
Fraser B. Fraser B. Science. 2016 Aug 12;353(6300):641-3. doi: 10.1126/science.353.6300.641. Science. 2016. PMID: 27516581 No abstract available.
Dams nudge Amazon's ecosystems off-kilter.
Fraser B. Fraser B. Science. 2018 Feb 2;359(6375):508-509. doi: 10.1126/science.359.6375.508. Epub 2018 Feb 1. Science. 2018. PMID: 29420273 No abstract available.
Diarrhea in Mechanically Ventilated Patients: A Nested Multicenter Substudy.
Dionne JC, Johnstone J, Heels-Ansdell D, Tahvildar Khazaneh P, Zytaruk N, Clarke F, Hand L, Millen T, Dechert W, Porteous R, Auld F, Hunt M, Campbell E, Bentall T, Campbell T, Smith O, Rose L, Arabi YM, Duan E, Wilcox ME, McIntyre L, Rochwerg B, Karachi T, Adhikari NK, Charbonney E, St-Arnaud C, Kristof A, Khwaja K, Marquis F, Zarychanski R, Golan E, Cook D; PROSPECT Research Coordinators Group, the PROSPECT Investigators and the Canadian Critical Care Trials Group. Dionne JC, et al. Crit Care Med. 2025 Jun 1;53(6):e1247-e1256. doi: 10.1097/CCM.0000000000006667. Epub 2025 Apr 3. Crit Care Med. 2025. PMID: 40459385 Clinical Trial.
Structural basis of TMPRSS11D specificity and autocleavage activation.
Fraser BJ, Wilson RP, Ferková S, Ilyassov O, Lac J, Dong A, Li YY, Seitova A, Li Y, Hejazi Z, Kenney TMG, Penn LZ, Edwards A, Leduc R, Boudreault PL, Morin GB, Bénard F, Arrowsmith CH. Fraser BJ, et al. Nat Commun. 2025 May 10;16(1):4351. doi: 10.1038/s41467-025-59677-3. Nat Commun. 2025. PMID: 40348740 Free PMC article.
From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants.
Lemieux G, Pérez-Vargas J, Désilets A, Hassanzadeh M, Thompson CAH, Gravel-Trudeau A, Joushomme A, Ennis S, Villanueva I, Marouseau É, Fraser BJ, Champagne W, Lepage M, Niikura M, Arrowsmith CH, Jean F, Leduc R, Boudreault PL. Lemieux G, et al. Among authors: fraser bj. J Med Chem. 2025 Apr 10;68(7):7119-7136. doi: 10.1021/acs.jmedchem.4c02468. Epub 2025 Mar 31. J Med Chem. 2025. PMID: 40163818
380 results