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Page 1
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA. Johannessen CM, et al. Among authors: golub t. Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627. Epub 2010 Nov 24. Nature. 2010. PMID: 21107320 Free PMC article.
Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma.
Beroukhim R, Getz G, Nghiemphu L, Barretina J, Hsueh T, Linhart D, Vivanco I, Lee JC, Huang JH, Alexander S, Du J, Kau T, Thomas RK, Shah K, Soto H, Perner S, Prensner J, Debiasi RM, Demichelis F, Hatton C, Rubin MA, Garraway LA, Nelson SF, Liau L, Mischel PS, Cloughesy TF, Meyerson M, Golub TA, Lander ES, Mellinghoff IK, Sellers WR. Beroukhim R, et al. Among authors: golub ta. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20007-12. doi: 10.1073/pnas.0710052104. Epub 2007 Dec 6. Proc Natl Acad Sci U S A. 2007. PMID: 18077431 Free PMC article.
Counterpoint: Data first.
Golub T. Golub T. Nature. 2010 Apr 1;464(7289):679. doi: 10.1038/464679a. Nature. 2010. PMID: 20360719 No abstract available.
Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer.
Oliver TG, Mercer KL, Sayles LC, Burke JR, Mendus D, Lovejoy KS, Cheng MH, Subramanian A, Mu D, Powers S, Crowley D, Bronson RT, Whittaker CA, Bhutkar A, Lippard SJ, Golub T, Thomale J, Jacks T, Sweet-Cordero EA. Oliver TG, et al. Among authors: golub t. Genes Dev. 2010 Apr 15;24(8):837-52. doi: 10.1101/gad.1897010. Genes Dev. 2010. PMID: 20395368 Free PMC article.
Integrative genome comparison of primary and metastatic melanomas.
Kabbarah O, Nogueira C, Feng B, Nazarian RM, Bosenberg M, Wu M, Scott KL, Kwong LN, Xiao Y, Cordon-Cardo C, Granter SR, Ramaswamy S, Golub T, Duncan LM, Wagner SN, Brennan C, Chin L. Kabbarah O, et al. Among authors: golub t. PLoS One. 2010 May 24;5(5):e10770. doi: 10.1371/journal.pone.0010770. PLoS One. 2010. PMID: 20520718 Free PMC article.
SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO.
Borck PC, Boyle I, Jankovic K, Bick N, Foster K, Lau AC, Parker-Burns LI, Lubicki DA, Li T, Borah AA, Lofaso NJ, Das Sharma S, Chan T, Kishen RV, Adeagbo A, Raghavan S, Aquilanti E, Prensner JR, Krill-Burger JM, Golub TR, Campbell CD, Dempster JM, Chan EM, Vazquez F. Borck PC, et al. Among authors: golub tr. Nature. 2025 Feb;638(8052):1104-1111. doi: 10.1038/s41586-024-08509-3. Epub 2025 Feb 5. Nature. 2025. PMID: 39910293 Free PMC article.
Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors.
Shanmugam V, Tokcan N, Chafamo D, Sullivan S, Borji M, Martin H, Newton G, Nadaf N, Hanbury S, Barrera I, Cable D, Weir J, Ashenberg O, Pinkus G, Rodig S, Uhler C, Macosko E, Shipp M, Louissaint A Jr, Chen F, Golub T. Shanmugam V, et al. Among authors: golub t. bioRxiv [Preprint]. 2025 Jan 25:2025.01.24.631210. doi: 10.1101/2025.01.24.631210. bioRxiv. 2025. PMID: 39896575 Free PMC article. Preprint.
BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models.
Rauh U, Wei G, Serrano-Wu M, Kosmidis G, Kaulfuss S, Siegel F, Thede K, McFarland J, Lemke CT, Werbeck N, Nowak-Reppel K, Pilari S, Menz S, Ocker M, Zhang W, Davis K, Poncet-Montange G, Roth J, Daniels D, Kaushik VK, Hubbard B, Ziegelbauer K, Golub TR. Rauh U, et al. Among authors: golub tr. Nat Cancer. 2024 Oct;5(10):1479-1493. doi: 10.1038/s43018-024-00814-0. Epub 2024 Aug 23. Nat Cancer. 2024. PMID: 39179926 Free PMC article.
350 results