Hardegger LA - Search Results

1

Halogen bonding at the active sites of human cathepsin L and MEK1 kinase: efficient interactions in different environments.

Hardegger LA, Kuhn B, Spinnler B, Anselm L, Ecabert R, Stihle M, Gsell B, Thoma R, Diez J, Benz J, Plancher JM, Hartmann G, Isshiki Y, Morikami K, Shimma N, Haap W, Banner DW, Diederich F. Hardegger LA, et al. ChemMedChem. 2011 Nov 4;6(11):2048-54. doi: 10.1002/cmdc.201100353. Epub 2011 Sep 6. ChemMedChem. 2011. PMID: 21898833

2

Systematic investigation of halogen bonding in protein-ligand interactions.

Hardegger LA, Kuhn B, Spinnler B, Anselm L, Ecabert R, Stihle M, Gsell B, Thoma R, Diez J, Benz J, Plancher JM, Hartmann G, Banner DW, Haap W, Diederich F. Hardegger LA, et al. Angew Chem Int Ed Engl. 2011 Jan 3;50(1):314-8. doi: 10.1002/anie.201006781. Angew Chem Int Ed Engl. 2011. PMID: 21184410 No abstract available.

3

Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.

Lauber BS, Hardegger LA, Alam KA, Lund BA, Dumele O, Harder M, Kuhn B, Engh RA, Diederich F. Lauber BS, et al. Among authors: hardegger la. Chemistry. 2016 Jan 4;22(1):211-21. doi: 10.1002/chem.201503552. Epub 2015 Nov 18. Chemistry. 2016. PMID: 26578105

4

Self-association based on orthogonal C=O...C=O interactions in the solid and liquid state.

Fäh C, Hardegger LA, Ebert MO, Schweizer WB, Diederich F. Fäh C, et al. Among authors: hardegger la. Chem Commun (Camb). 2010 Jan 7;46(1):67-9. doi: 10.1039/b912721f. Epub 2009 Nov 6. Chem Commun (Camb). 2010. PMID: 20024295

5

New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates.

Fäh C, Hardegger LA, Baitsch L, Schweizer WB, Meyer S, Bur D, Diederich F. Fäh C, et al. Among authors: hardegger la. Org Biomol Chem. 2009 Oct 7;7(19):3947-57. doi: 10.1039/b908489d. Epub 2009 Jul 24. Org Biomol Chem. 2009. PMID: 19763297

6

Corrigendum: Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.

Lauber BS, Hardegger LA, Alam KA, Lund BA, Dumele O, Harder M, Kuhn B, Engh RA, Diederich F. Lauber BS, et al. Among authors: hardegger la. Chemistry. 2020 Jul 14;26(39):8664. doi: 10.1002/chem.202002162. Epub 2020 Jul 2. Chemistry. 2020. PMID: 32662107 No abstract available.

7

The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.

Adams CM, Anderson K, Artman G 3rd, Bizec JC, Cepeda R, Elliott J, Fassbender E, Ghosh M, Hanks S, Hardegger LA, Hosagrahara VP, Jaffee B, Jendza K, Ji N, Johnson L, Lee W, Liu D, Liu F, Long D, Ma F, Mainolfi N, Meredith EL, Miranda K, Peng Y, Poor S, Powers J, Qiu Y, Rao C, Shen S, Sivak JM, Solovay C, Tarsa P, Woolfenden A, Zhang C, Zhang Y. Adams CM, et al. Among authors: hardegger la. J Med Chem. 2018 Feb 22;61(4):1622-1635. doi: 10.1021/acs.jmedchem.7b01731. Epub 2018 Feb 5. J Med Chem. 2018. PMID: 29400470

8

Modular Synthesis of Highly Substituted Pyridines via Enolate α-Alkenylation.

Hardegger LA, Habegger J, Donohoe TJ. Hardegger LA, et al. Org Lett. 2015 Jul 2;17(13):3222-5. doi: 10.1021/acs.orglett.5b01312. Epub 2015 Jun 18. Org Lett. 2015. PMID: 26087079

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