Kozikowski AP - Search Results

1

Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells.

Kalin JH, Butler KV, Akimova T, Hancock WW, Kozikowski AP. Kalin JH, et al. Among authors: kozikowski ap. J Med Chem. 2012 Jan 26;55(2):639-51. doi: 10.1021/jm200773h. Epub 2012 Jan 5. J Med Chem. 2012. PMID: 22165909

2

Chemical origins of isoform selectivity in histone deacetylase inhibitors.

Butler KV, Kozikowski AP. Butler KV, et al. Among authors: kozikowski ap. Curr Pharm Des. 2008;14(6):505-28. doi: 10.2174/138161208783885353. Curr Pharm Des. 2008. PMID: 18336297 Review.

3

Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.

Butler KV, Kalin J, Brochier C, Vistoli G, Langley B, Kozikowski AP. Butler KV, et al. Among authors: kozikowski ap. J Am Chem Soc. 2010 Aug 11;132(31):10842-6. doi: 10.1021/ja102758v. J Am Chem Soc. 2010. PMID: 20614936 Free PMC article.

4

Chiral mercaptoacetamides display enantioselective inhibition of histone deacetylase 6 and exhibit neuroprotection in cortical neuron models of oxidative stress.

Kalin JH, Zhang H, Gaudrel-Grosay S, Vistoli G, Kozikowski AP. Kalin JH, et al. Among authors: kozikowski ap. ChemMedChem. 2012 Mar 5;7(3):425-39. doi: 10.1002/cmdc.201100522. Epub 2012 Jan 10. ChemMedChem. 2012. PMID: 22234885

5

Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease.

Shen S, Benoy V, Bergman JA, Kalin JH, Frojuello M, Vistoli G, Haeck W, Van Den Bosch L, Kozikowski AP. Shen S, et al. Among authors: kozikowski ap. ACS Chem Neurosci. 2016 Feb 17;7(2):240-58. doi: 10.1021/acschemneuro.5b00286. Epub 2015 Dec 7. ACS Chem Neurosci. 2016. PMID: 26599234 Free PMC article.

6

Thiol-Based Potent and Selective HDAC6 Inhibitors Promote Tubulin Acetylation and T-Regulatory Cell Suppressive Function.

Segretti MC, Vallerini GP, Brochier C, Langley B, Wang L, Hancock WW, Kozikowski AP. Segretti MC, et al. Among authors: kozikowski ap. ACS Med Chem Lett. 2015 Oct 5;6(11):1156-61. doi: 10.1021/acsmedchemlett.5b00303. eCollection 2015 Nov 12. ACS Med Chem Lett. 2015. PMID: 26617971 Free PMC article.

7

Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function.

Huang J, Wang L, Dahiya S, Beier UH, Han R, Samanta A, Bergman J, Sotomayor EM, Seto E, Kozikowski AP, Hancock WW. Huang J, et al. Among authors: kozikowski ap. Sci Rep. 2017 Aug 17;7(1):8626. doi: 10.1038/s41598-017-09211-3. Sci Rep. 2017. PMID: 28819166 Free PMC article.

8

Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.

Kozikowski AP, Tapadar S, Luchini DN, Kim KH, Billadeau DD. Kozikowski AP, et al. J Med Chem. 2008 Aug 14;51(15):4370-3. doi: 10.1021/jm8002894. Epub 2008 Jul 22. J Med Chem. 2008. PMID: 18642892 Free PMC article.

9

Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation.

Tang H, Wang XS, Huang XP, Roth BL, Butler KV, Kozikowski AP, Jung M, Tropsha A. Tang H, et al. Among authors: kozikowski ap. J Chem Inf Model. 2009 Feb;49(2):461-76. doi: 10.1021/ci800366f. J Chem Inf Model. 2009. PMID: 19182860

10

Stereoselective HDAC inhibition from cysteine-derived zinc-binding groups.

Butler KV, He R, McLaughlin K, Vistoli G, Langley B, Kozikowski AP. Butler KV, et al. Among authors: kozikowski ap. ChemMedChem. 2009 Aug;4(8):1292-301. doi: 10.1002/cmdc.200900088. ChemMedChem. 2009. PMID: 19551801

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