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Acidity generated by the tumor microenvironment drives local invasion.
Estrella V, Chen T, Lloyd M, Wojtkowiak J, Cornnell HH, Ibrahim-Hashim A, Bailey K, Balagurunathan Y, Rothberg JM, Sloane BF, Johnson J, Gatenby RA, Gillies RJ. Estrella V, et al. Among authors: sloane bf. Cancer Res. 2013 Mar 1;73(5):1524-35. doi: 10.1158/0008-5472.CAN-12-2796. Epub 2013 Jan 3. Cancer Res. 2013. PMID: 23288510 Free PMC article.
I2 imaging: cancer biology and the tumor microenvironment.
Sloane BF, Gillies RJ, Mohla S, Sogn JA, Menkens AE, Sullivan DC. Sloane BF, et al. Cancer Res. 2006 Dec 1;66(23):11097-9. doi: 10.1158/0008-5472.CAN-06-3102. Epub 2006 Nov 17. Cancer Res. 2006. PMID: 17114235
Bicarbonate increases tumor pH and inhibits spontaneous metastases.
Robey IF, Baggett BK, Kirkpatrick ND, Roe DJ, Dosescu J, Sloane BF, Hashim AI, Morse DL, Raghunand N, Gatenby RA, Gillies RJ. Robey IF, et al. Among authors: sloane bf. Cancer Res. 2009 Mar 15;69(6):2260-8. doi: 10.1158/0008-5472.CAN-07-5575. Epub 2009 Mar 10. Cancer Res. 2009. PMID: 19276390 Free PMC article.
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.
Wojtkowiak JW, Rothberg JM, Kumar V, Schramm KJ, Haller E, Proemsey JB, Lloyd MC, Sloane BF, Gillies RJ. Wojtkowiak JW, et al. Among authors: sloane bf. Cancer Res. 2012 Aug 15;72(16):3938-47. doi: 10.1158/0008-5472.CAN-11-3881. Epub 2012 Jun 19. Cancer Res. 2012. PMID: 22719070 Free PMC article.
Acid-mediated tumor proteolysis: contribution of cysteine cathepsins.
Rothberg JM, Bailey KM, Wojtkowiak JW, Ben-Nun Y, Bogyo M, Weber E, Moin K, Blum G, Mattingly RR, Gillies RJ, Sloane BF. Rothberg JM, et al. Among authors: sloane bf. Neoplasia. 2013 Oct;15(10):1125-37. doi: 10.1593/neo.13946. Neoplasia. 2013. PMID: 24204192 Free PMC article.
217 results