O'Keeffe S - Search Results

1

Intricate interplay between astrocytes and motor neurons in ALS.

Phatnani HP, Guarnieri P, Friedman BA, Carrasco MA, Muratet M, O'Keeffe S, Nwakeze C, Pauli-Behn F, Newberry KM, Meadows SK, Tapia JC, Myers RM, Maniatis T. Phatnani HP, et al. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E756-65. doi: 10.1073/pnas.1222361110. Epub 2013 Feb 6. Proc Natl Acad Sci U S A. 2013. PMID: 23388633 Free PMC article.

2

Accelerated high-yield generation of limb-innervating motor neurons from human stem cells.

Amoroso MW, Croft GF, Williams DJ, O'Keeffe S, Carrasco MA, Davis AR, Roybon L, Oakley DH, Maniatis T, Henderson CE, Wichterle H. Amoroso MW, et al. J Neurosci. 2013 Jan 9;33(2):574-86. doi: 10.1523/JNEUROSCI.0906-12.2013. J Neurosci. 2013. PMID: 23303937 Free PMC article.

3

A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model.

Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, Myers RM, Maniatis T. Chiu IM, et al. Cell Rep. 2013 Jul 25;4(2):385-401. doi: 10.1016/j.celrep.2013.06.018. Epub 2013 Jul 11. Cell Rep. 2013. PMID: 23850290 Free PMC article.

4

An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.

Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S, Phatnani HP, Guarnieri P, Caneda C, Ruderisch N, Deng S, Liddelow SA, Zhang C, Daneman R, Maniatis T, Barres BA, Wu JQ. Zhang Y, et al. J Neurosci. 2014 Sep 3;34(36):11929-47. doi: 10.1523/JNEUROSCI.1860-14.2014. J Neurosci. 2014. PMID: 25186741 Free PMC article.

5

hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function.

Ye J, Beetz N, O'Keeffe S, Tapia JC, Macpherson L, Chen WV, Bassel-Duby R, Olson EN, Maniatis T. Ye J, et al. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3020-9. doi: 10.1073/pnas.1508461112. Epub 2015 May 26. Proc Natl Acad Sci U S A. 2015. PMID: 26039991 Free PMC article.

6

Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice.

Chen WV, Nwakeze CL, Denny CA, O'Keeffe S, Rieger MA, Mountoufaris G, Kirner A, Dougherty JD, Hen R, Wu Q, Maniatis T. Chen WV, et al. Science. 2017 Apr 28;356(6336):406-411. doi: 10.1126/science.aal3231. Science. 2017. PMID: 28450636 Free PMC article.

7

Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly.

Mountoufaris G, Chen WV, Hirabayashi Y, O'Keeffe S, Chevee M, Nwakeze CL, Polleux F, Maniatis T. Mountoufaris G, et al. Science. 2017 Apr 28;356(6336):411-414. doi: 10.1126/science.aai8801. Science. 2017. PMID: 28450637 Free PMC article.

8

Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin α Promoter Choice.

Canzio D, Nwakeze CL, Horta A, Rajkumar SM, Coffey EL, Duffy EE, Duffié R, Monahan K, O'Keeffe S, Simon MD, Lomvardas S, Maniatis T. Canzio D, et al. Cell. 2019 Apr 18;177(3):639-653.e15. doi: 10.1016/j.cell.2019.03.008. Epub 2019 Apr 4. Cell. 2019. PMID: 30955885 Free PMC article.

9

The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice.

Gerbino V, Kaunga E, Ye J, Canzio D, O'Keeffe S, Rudnick ND, Guarnieri P, Lutz CM, Maniatis T. Gerbino V, et al. Neuron. 2020 Jun 3;106(5):789-805.e5. doi: 10.1016/j.neuron.2020.03.005. Epub 2020 Mar 27. Neuron. 2020. PMID: 32220666 Free article.

10

Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants.

Liu H, Abedini A, Ha E, Ma Z, Sheng X, Dumoulin B, Qiu C, Aranyi T, Li S, Dittrich N, Chen HC, Tao R, Tarng DC, Hsieh FJ, Chen SA, Yang SF, Lee MY, Kwok PY, Wu JY, Chen CH, Khan A, Limdi NA, Wei WQ, Walunas TL, Karlson EW, Kenny EE, Luo Y, Kottyan L, Connolly JJ, Jarvik GP, Weng C, Shang N, Cole JB, Mercader JM, Mandla R, Majarian TD, Florez JC, Haas ME, Lotta LA; Regeneron Genetics Center‡; GHS-RGC DiscovEHR Collaboration§; Drivas TG; Penn Medicine BioBank¶; Vy HMT, Nadkarni GN, Wiley LK, Wilson MP, Gignoux CR, Rasheed H, Thomas LF, Åsvold BO, Brumpton BM, Hallan SI, Hveem K, Zheng J, Hellwege JN, Zawistowski M, Zöllner S, Franceschini N, Hu H, Zhou J, Kiryluk K, Ritchie MD, Palmer M, Edwards TL, Voight BF, Hung AM, Susztak K; Regeneron Genetics Center; GHS-RGC DiscovEHR Collaboration; Penn Medicine BioBank. Liu H, et al. Science. 2025 Feb 7;387(6734):eadp4753. doi: 10.1126/science.adp4753. Epub 2025 Feb 7. Science. 2025. PMID: 39913582

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