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Page 1
Local proliferation dominates lesional macrophage accumulation in atherosclerosis.
Robbins CS, Hilgendorf I, Weber GF, Theurl I, Iwamoto Y, Figueiredo JL, Gorbatov R, Sukhova GK, Gerhardt LM, Smyth D, Zavitz CC, Shikatani EA, Parsons M, van Rooijen N, Lin HY, Husain M, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Robbins CS, et al. Among authors: gerhardt lm. Nat Med. 2013 Sep;19(9):1166-72. doi: 10.1038/nm.3258. Epub 2013 Aug 11. Nat Med. 2013. PMID: 23933982 Free PMC article.
Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity.
Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum JL, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Hilgendorf I, et al. Among authors: gerhardt lm. Circulation. 2014 Apr 22;129(16):1677-87. doi: 10.1161/CIRCULATIONAHA.113.006381. Epub 2014 Jan 31. Circulation. 2014. PMID: 24488984 Free PMC article.
Atheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression.
Lindau A, Härdtner C, Hergeth SP, Blanz KD, Dufner B, Hoppe N, Anto-Michel N, Kornemann J, Zou J, Gerhardt LM, Heidt T, Willecke F, Geis S, Stachon P, Wolf D, Libby P, Swirski FK, Robbins CS, McPheat W, Hawley S, Braddock M, Gilsbach R, Hein L, von zur Mühlen C, Bode C, Zirlik A, Hilgendorf I. Lindau A, et al. Among authors: gerhardt lm. Basic Res Cardiol. 2016 Mar;111(2):20. doi: 10.1007/s00395-016-0535-8. Epub 2016 Feb 18. Basic Res Cardiol. 2016. PMID: 26891724 Free PMC article.
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.
Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK. Theurl I, et al. Among authors: gerhardt lm. Nat Med. 2016 Aug;22(8):945-51. doi: 10.1038/nm.4146. Epub 2016 Jul 18. Nat Med. 2016. PMID: 27428900 Free PMC article.
Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium.
Hilgendorf I, Gerhardt LM, Tan TC, Winter C, Holderried TA, Chousterman BG, Iwamoto Y, Liao R, Zirlik A, Scherer-Crosbie M, Hedrick CC, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Hilgendorf I, et al. Among authors: gerhardt lm. Circ Res. 2014 May 9;114(10):1611-22. doi: 10.1161/CIRCRESAHA.114.303204. Epub 2014 Mar 13. Circ Res. 2014. PMID: 24625784 Free PMC article.
Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis.
Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK. Weber GF, et al. Among authors: gerhardt lm. J Exp Med. 2014 Jun 2;211(6):1243-56. doi: 10.1084/jem.20131471. Epub 2014 May 12. J Exp Med. 2014. PMID: 24821911 Free PMC article.
Anaemia predicts iron homoeostasis dysregulation and modulates the response to empagliflozin in heart failure with reduced ejection fraction: the EMPATROPISM-FE trial.
Angermann CE, Sehner S, Gerhardt LMS, Santos-Gallego CG, Requena-Ibanez JA, Zeller T, Maack C, Sanz J, Frantz S, Ertl G, Badimon JJ. Angermann CE, et al. Among authors: gerhardt lms. Eur Heart J. 2025 Apr 22;46(16):1507-1523. doi: 10.1093/eurheartj/ehae917. Eur Heart J. 2025. PMID: 39907687 Free PMC article. Clinical Trial.
27 results