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Page 1
Preclinical evaluation of the epithelial sodium channel inhibitor AZD5634 and implications on human translation.
Åstrand A, Libby EF, Shei RJ, Lever JEP, Kaza N, Adewale AT, Boitet E, Edwards L, Hemmerling M, Root J, Lindberg B, Wingren C, Malmgren A, Sabater J, Rowe SM. Åstrand A, et al. Among authors: root j. Am J Physiol Lung Cell Mol Physiol. 2022 Nov 1;323(5):L536-L547. doi: 10.1152/ajplung.00454.2021. Epub 2022 Sep 13. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 36098422 Free PMC article.
Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs.
Fernández-Blanco JA, Fakih D, Arike L, Rodríguez-Piñeiro AM, Martínez-Abad B, Skansebo E, Jackson S, Root J, Singh D, McCrae C, Evans CM, Åstrand A, Ermund A, Hansson GC. Fernández-Blanco JA, et al. Among authors: root j. JCI Insight. 2018 Sep 6;3(17):e120994. doi: 10.1172/jci.insight.120994. eCollection 2018 Sep 6. JCI Insight. 2018. PMID: 30185674 Free PMC article.
Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure-Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects.
Palmér R, Mäenpää J, Jauhiainen A, Larsson B, Mo J, Russell M, Root J, Prothon S, Chialda L, Forte P, Egelrud T, Stenvall K, Gardiner P. Palmér R, et al. Among authors: root j. Clin Pharmacol Ther. 2018 Dec;104(6):1155-1164. doi: 10.1002/cpt.1053. Epub 2018 Apr 16. Clin Pharmacol Ther. 2018. PMID: 29484635 Free PMC article. Clinical Trial.
Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors.
Storer RI, Brennan PE, Brown AD, Bungay PJ, Conlon KM, Corbett MS, DePianta RP, Fish PV, Heifetz A, Ho DK, Jessiman AS, McMurray G, de Oliveira CA, Roberts LR, Root JA, Shanmugasundaram V, Shapiro MJ, Skerten M, Westbrook D, Wheeler S, Whitlock GA, Wright J. Storer RI, et al. Among authors: root ja. J Med Chem. 2014 Jun 26;57(12):5258-69. doi: 10.1021/jm5003292. Epub 2014 Jun 17. J Med Chem. 2014. PMID: 24878222
Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence.
Andrews MD, Fish PV, Blagg J, Brabham TK, Brennan PE, Bridgeland A, Brown AD, Bungay PJ, Conlon KM, Edmunds NJ, af Forselles K, Gibbons CP, Green MP, Hanton G, Holbrook M, Jessiman AS, McIntosh K, McMurray G, Nichols CL, Root JA, Storer RI, Sutton MR, Ward RV, Westbrook D, Whitlock GA. Andrews MD, et al. Among authors: root ja. Bioorg Med Chem Lett. 2011 May 1;21(9):2715-20. doi: 10.1016/j.bmcl.2010.11.120. Epub 2010 Dec 4. Bioorg Med Chem Lett. 2011. PMID: 21195614
352 results