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Page 1
Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease.
Hill RM, Kuijper S, Lindsey JC, Petrie K, Schwalbe EC, Barker K, Boult JK, Williamson D, Ahmad Z, Hallsworth A, Ryan SL, Poon E, Robinson SP, Ruddle R, Raynaud FI, Howell L, Kwok C, Joshi A, Nicholson SL, Crosier S, Ellison DW, Wharton SB, Robson K, Michalski A, Hargrave D, Jacques TS, Pizer B, Bailey S, Swartling FJ, Weiss WA, Chesler L, Clifford SC. Hill RM, et al. Among authors: nicholson sl. Cancer Cell. 2015 Jan 12;27(1):72-84. doi: 10.1016/j.ccell.2014.11.002. Epub 2014 Dec 18. Cancer Cell. 2015. PMID: 25533335 Free PMC article.
MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma.
Ryan SL, Schwalbe EC, Cole M, Lu Y, Lusher ME, Megahed H, O'Toole K, Nicholson SL, Bognar L, Garami M, Hauser P, Korshunov A, Pfister SM, Williamson D, Taylor RE, Ellison DW, Bailey S, Clifford SC. Ryan SL, et al. Among authors: nicholson sl. Acta Neuropathol. 2012 Apr;123(4):501-13. doi: 10.1007/s00401-011-0923-y. Epub 2011 Dec 3. Acta Neuropathol. 2012. PMID: 22139329
Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types.
Schwalbe EC, Hayden JT, Rogers HA, Miller S, Lindsey JC, Hill RM, Nicholson SL, Kilday JP, Adamowicz-Brice M, Storer L, Jacques TS, Robson K, Lowe J, Williamson D, Grundy RG, Bailey S, Clifford SC. Schwalbe EC, et al. Among authors: nicholson sl. Acta Neuropathol. 2013 Dec;126(6):943-6. doi: 10.1007/s00401-013-1206-6. Epub 2013 Nov 9. Acta Neuropathol. 2013. PMID: 24212602 Free PMC article. No abstract available.
Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial.
Clifford SC, Lannering B, Schwalbe EC, Hicks D, O'Toole K, Nicholson SL, Goschzik T, Zur Mühlen A, Figarella-Branger D, Doz F, Rutkowski S, Gustafsson G, Pietsch T; SIOP-Europe PNET Group. Clifford SC, et al. Among authors: nicholson sl. Oncotarget. 2015 Nov 17;6(36):38827-39. doi: 10.18632/oncotarget.5149. Oncotarget. 2015. PMID: 26420814 Free PMC article. Clinical Trial.
Recurrent humid phases in Arabia over the past 8 million years.
Markowska M, Vonhof HB, Groucutt HS, Breeze PS, Drake N, Stewart M, Albert R, Andrieux E, Blinkhorn J, Boivin N, Budsky A, Clark-Wilson R, Fleitmann D, Gerdes A, Martin AN, Martínez-García A, Nicholson SL, Price GJ, Scerri EML, Scholz D, Vanwezer N, Weber M, Alsharekh AM, Al Omari AA, Al-Mufarreh YSA, Al-Jibreen F, Alqahtani M, Al-Shanti M, Zalmout I, Petraglia MD, Haug GH. Markowska M, et al. Among authors: nicholson sl. Nature. 2025 Apr;640(8060):954-961. doi: 10.1038/s41586-025-08859-6. Epub 2025 Apr 9. Nature. 2025. PMID: 40205061 Free PMC article.
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