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Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety.
Shen EY, Jiang Y, Javidfar B, Kassim B, Loh YE, Ma Q, Mitchell AC, Pothula V, Stewart AF, Ernst P, Yao WD, Martin G, Shen L, Jakovcevski M, Akbarian S. Shen EY, et al. Among authors: stewart af. Neuropsychopharmacology. 2016 Dec;41(13):3103-3113. doi: 10.1038/npp.2016.144. Epub 2016 Aug 3. Neuropsychopharmacology. 2016. PMID: 27485686 Free PMC article.
Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice.
Kerimoglu C, Agis-Balboa RC, Kranz A, Stilling R, Bahari-Javan S, Benito-Garagorri E, Halder R, Burkhardt S, Stewart AF, Fischer A. Kerimoglu C, et al. Among authors: stewart af. J Neurosci. 2013 Feb 20;33(8):3452-64. doi: 10.1523/JNEUROSCI.3356-12.2013. J Neurosci. 2013. PMID: 23426673 Free PMC article.
MLL1 is required for maintenance of intestinal stem cells.
Goveas N, Waskow C, Arndt K, Heuberger J, Zhang Q, Alexopoulou D, Dahl A, Birchmeier W, Anastassiadis K, Stewart AF, Kranz A. Goveas N, et al. Among authors: stewart af. PLoS Genet. 2021 Dec 3;17(12):e1009250. doi: 10.1371/journal.pgen.1009250. eCollection 2021 Dec. PLoS Genet. 2021. PMID: 34860830 Free PMC article.
KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions.
Kerimoglu C, Sakib MS, Jain G, Benito E, Burkhardt S, Capece V, Kaurani L, Halder R, Agís-Balboa RC, Stilling R, Urbanke H, Kranz A, Stewart AF, Fischer A. Kerimoglu C, et al. Among authors: stewart af. Cell Rep. 2017 Jul 18;20(3):538-548. doi: 10.1016/j.celrep.2017.06.072. Cell Rep. 2017. PMID: 28723559 Free article.
Postnatal expression of the lysine methyltransferase SETD1B is essential for learning and the regulation of neuron-enriched genes.
Michurina A, Sakib MS, Kerimoglu C, Krüger DM, Kaurani L, Islam MR, Joshi PD, Schröder S, Centeno TP, Zhou J, Pradhan R, Cha J, Xu X, Eichele G, Zeisberg EM, Kranz A, Stewart AF, Fischer A. Michurina A, et al. Among authors: stewart af. EMBO J. 2022 Jan 4;41(1):e106459. doi: 10.15252/embj.2020106459. Epub 2021 Nov 22. EMBO J. 2022. PMID: 34806773 Free PMC article.
616 results