Eilers M - Search Results

1

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.

Richards MW, Burgess SG, Poon E, Carstensen A, Eilers M, Chesler L, Bayliss R. Richards MW, et al. Among authors: eilers m. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13726-13731. doi: 10.1073/pnas.1610626113. Epub 2016 Nov 11. Proc Natl Acad Sci U S A. 2016. PMID: 27837025 Free PMC article.

2

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma.

Otto T, Horn S, Brockmann M, Eilers U, Schüttrumpf L, Popov N, Kenney AM, Schulte JH, Beijersbergen R, Christiansen H, Berwanger B, Eilers M. Otto T, et al. Among authors: eilers u, eilers m. Cancer Cell. 2009 Jan 6;15(1):67-78. doi: 10.1016/j.ccr.2008.12.005. Cancer Cell. 2009. PMID: 19111882 Free article.

3

Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover.

Popov N, Schülein C, Jaenicke LA, Eilers M. Popov N, et al. Among authors: eilers m. Nat Cell Biol. 2010 Oct;12(10):973-81. doi: 10.1038/ncb2104. Epub 2010 Sep 19. Nat Cell Biol. 2010. PMID: 20852628

4

Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma.

Brockmann M, Poon E, Berry T, Carstensen A, Deubzer HE, Rycak L, Jamin Y, Thway K, Robinson SP, Roels F, Witt O, Fischer M, Chesler L, Eilers M. Brockmann M, et al. Among authors: eilers m. Cancer Cell. 2013 Jul 8;24(1):75-89. doi: 10.1016/j.ccr.2013.05.005. Epub 2013 Jun 20. Cancer Cell. 2013. PMID: 23792191 Free PMC article.

5

Drugging MYCN through an allosteric transition in Aurora kinase A.

Gustafson WC, Meyerowitz JG, Nekritz EA, Chen J, Benes C, Charron E, Simonds EF, Seeger R, Matthay KK, Hertz NT, Eilers M, Shokat KM, Weiss WA. Gustafson WC, et al. Among authors: eilers m. Cancer Cell. 2014 Sep 8;26(3):414-427. doi: 10.1016/j.ccr.2014.07.015. Epub 2014 Aug 28. Cancer Cell. 2014. PMID: 25175806 Free PMC article.

6

Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.

Jaenicke LA, von Eyss B, Carstensen A, Wolf E, Xu W, Greifenberg AK, Geyer M, Eilers M, Popov N. Jaenicke LA, et al. Among authors: eilers m. Mol Cell. 2016 Jan 7;61(1):54-67. doi: 10.1016/j.molcel.2015.11.007. Epub 2015 Dec 10. Mol Cell. 2016. PMID: 26687678 Free article.

7

A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.

Dauch D, Rudalska R, Cossa G, Nault JC, Kang TW, Wuestefeld T, Hohmeyer A, Imbeaud S, Yevsa T, Hoenicke L, Pantsar T, Bozko P, Malek NP, Longerich T, Laufer S, Poso A, Zucman-Rossi J, Eilers M, Zender L. Dauch D, et al. Among authors: eilers m. Nat Med. 2016 Jul;22(7):744-53. doi: 10.1038/nm.4107. Epub 2016 May 23. Nat Med. 2016. PMID: 27213815

8

Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma.

Brockmann M, Poon E, Berry T, Carstensen A, Deubzer HE, Rycak L, Jamin Y, Thway K, Robinson SP, Roels F, Witt O, Fischer M, Chesler L, Eilers M. Brockmann M, et al. Among authors: eilers m. Cancer Cell. 2016 Aug 8;30(2):357-358. doi: 10.1016/j.ccell.2016.07.002. Epub 2016 Aug 8. Cancer Cell. 2016. PMID: 27505677 Free article. No abstract available.

9

Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project.

Moreno L, Caron H, Geoerger B, Eggert A, Schleiermacher G, Brock P, Valteau-Couanet D, Chesler L, Schulte JH, De Preter K, Molenaar J, Schramm A, Eilers M, Van Maerken T, Johnsen JI, Garrett M, George SL, Tweddle DA, Kogner P, Berthold F, Koster J, Barone G, Tucker ER, Marshall L, Herold R, Sterba J, Norga K, Vassal G, Pearson AD. Moreno L, et al. Among authors: eilers m. Expert Opin Drug Discov. 2017 Aug;12(8):801-811. doi: 10.1080/17460441.2017.1340269. Epub 2017 Jun 26. Expert Opin Drug Discov. 2017. PMID: 28604107 Free article. Review.

10

Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle.

Büchel G, Carstensen A, Mak KY, Roeschert I, Leen E, Sumara O, Hofstetter J, Herold S, Kalb J, Baluapuri A, Poon E, Kwok C, Chesler L, Maric HM, Rickman DS, Wolf E, Bayliss R, Walz S, Eilers M. Büchel G, et al. Among authors: eilers m. Cell Rep. 2017 Dec 19;21(12):3483-3497. doi: 10.1016/j.celrep.2017.11.090. Cell Rep. 2017. PMID: 29262328 Free PMC article.

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