Phillips AM - Search Results

1

Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones.

Phillips AM, Ponomarenko AI, Chen K, Ashenberg O, Miao J, McHugh SM, Butty VL, Whittaker CA, Moore CL, Bloom JD, Lin YS, Shoulders MD. Phillips AM, et al. PLoS Biol. 2018 Sep 17;16(9):e3000008. doi: 10.1371/journal.pbio.3000008. eCollection 2018 Sep. PLoS Biol. 2018. PMID: 30222731 Free PMC article.

2

The Path of Least Resistance: Mechanisms to Reduce Influenza's Sensitivity to Oseltamivir.

Phillips AM, Shoulders MD. Phillips AM, et al. J Mol Biol. 2016 Feb 13;428(3):533-537. doi: 10.1016/j.jmb.2015.12.019. Epub 2015 Dec 31. J Mol Biol. 2016. PMID: 26748011 Free PMC article. No abstract available.

3

Host proteostasis modulates influenza evolution.

Phillips AM, Gonzalez LO, Nekongo EE, Ponomarenko AI, McHugh SM, Butty VL, Levine SS, Lin YS, Mirny LA, Shoulders MD. Phillips AM, et al. Elife. 2017 Sep 26;6:e28652. doi: 10.7554/eLife.28652. Elife. 2017. PMID: 28949290 Free PMC article.

4

Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin.

Phillips AM, Doud MB, Gonzalez LO, Butty VL, Lin YS, Bloom JD, Shoulders MD. Phillips AM, et al. Elife. 2018 Sep 6;7:e38795. doi: 10.7554/eLife.38795. Elife. 2018. PMID: 30188321 Free PMC article.

5

The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope.

Yoon J, Nekongo EE, Patrick JE, Hui T, Phillips AM, Ponomarenko AI, Hendel SJ, Sebastian RM, Zhang YM, Butty VL, Ogbunugafor CB, Lin YS, Shoulders MD. Yoon J, et al. Among authors: phillips am. PLoS Biol. 2022 Feb 18;20(2):e3001569. doi: 10.1371/journal.pbio.3001569. eCollection 2022 Feb. PLoS Biol. 2022. PMID: 35180219 Free PMC article.

6

Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1.

Moulana A, Dupic T, Phillips AM, Chang J, Nieves S, Roffler AA, Greaney AJ, Starr TN, Bloom JD, Desai MM. Moulana A, et al. Among authors: phillips am. Nat Commun. 2022 Nov 16;13(1):7011. doi: 10.1038/s41467-022-34506-z. Nat Commun. 2022. PMID: 36384919 Free PMC article.

7

The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA.1 evolution.

Moulana A, Dupic T, Phillips AM, Chang J, Roffler AA, Greaney AJ, Starr TN, Bloom JD, Desai MM. Moulana A, et al. Among authors: phillips am. Elife. 2023 Feb 21;12:e83442. doi: 10.7554/eLife.83442. Elife. 2023. PMID: 36803543 Free PMC article.

8

Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations.

Johnson MS, Gopalakrishnan S, Goyal J, Dillingham ME, Bakerlee CW, Humphrey PT, Jagdish T, Jerison ER, Kosheleva K, Lawrence KR, Min J, Moulana A, Phillips AM, Piper JC, Purkanti R, Rego-Costa A, McDonald MJ, Nguyen Ba AN, Desai MM. Johnson MS, et al. Among authors: phillips am. Elife. 2021 Jan 19;10:e63910. doi: 10.7554/eLife.63910. Elife. 2021. PMID: 33464204 Free PMC article.

9

Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies.

Phillips AM, Lawrence KR, Moulana A, Dupic T, Chang J, Johnson MS, Cvijovic I, Mora T, Walczak AM, Desai MM. Phillips AM, et al. Elife. 2021 Sep 7;10:e71393. doi: 10.7554/eLife.71393. Elife. 2021. PMID: 34491198 Free PMC article.

10

Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody.

Phillips AM, Maurer DP, Brooks C, Dupic T, Schmidt AG, Desai MM. Phillips AM, et al. Elife. 2023 Jan 10;12:e83628. doi: 10.7554/eLife.83628. Elife. 2023. PMID: 36625542 Free PMC article.

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