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Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.
Cantù C, Felker A, Zimmerli D, Prummel KD, Cabello EM, Chiavacci E, Méndez-Acevedo KM, Kirchgeorg L, Burger S, Ripoll J, Valenta T, Hausmann G, Vilain N, Aguet M, Burger A, Panáková D, Basler K, Mosimann C. Cantù C, et al. Among authors: prummel kd. Genes Dev. 2018 Nov 1;32(21-22):1443-1458. doi: 10.1101/gad.315531.118. Epub 2018 Oct 26. Genes Dev. 2018. PMID: 30366904 Free PMC article.
The lateral plate mesoderm.
Prummel KD, Nieuwenhuize S, Mosimann C. Prummel KD, et al. Development. 2020 Jun 19;147(12):dev175059. doi: 10.1242/dev.175059. Development. 2020. PMID: 32561665 Free PMC article. Review.
A conserved regulatory program initiates lateral plate mesoderm emergence across chordates.
Prummel KD, Hess C, Nieuwenhuize S, Parker HJ, Rogers KW, Kozmikova I, Racioppi C, Brombacher EC, Czarkwiani A, Knapp D, Burger S, Chiavacci E, Shah G, Burger A, Huisken J, Yun MH, Christiaen L, Kozmik Z, Müller P, Bronner M, Krumlauf R, Mosimann C. Prummel KD, et al. Nat Commun. 2019 Aug 26;10(1):3857. doi: 10.1038/s41467-019-11561-7. Nat Commun. 2019. PMID: 31451684 Free PMC article.
Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma.
Prummel KD, Crowell HL, Nieuwenhuize S, Brombacher EC, Daetwyler S, Soneson C, Kresoja-Rakic J, Kocere A, Ronner M, Ernst A, Labbaf Z, Clouthier DE, Firulli AB, Sánchez-Iranzo H, Naganathan SR, O'Rourke R, Raz E, Mercader N, Burger A, Felley-Bosco E, Huisken J, Robinson MD, Mosimann C. Prummel KD, et al. Nat Commun. 2022 Mar 30;13(1):1677. doi: 10.1038/s41467-022-29311-7. Nat Commun. 2022. PMID: 35354817 Free PMC article.
Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics.
Lobato-Moreno S, Yildiz U, Claringbould A, Servaas NH, Vlachou EP, Arnold C, Bauersachs HG, Campos-Fornés V, Kim M, Berest I, Prummel KD, Noh KM, Marttinen M, Zaugg JB. Lobato-Moreno S, et al. Among authors: prummel kd. Nat Methods. 2025 Jun;22(6):1213-1225. doi: 10.1038/s41592-025-02700-8. Epub 2025 May 26. Nat Methods. 2025. PMID: 40419657 Free PMC article.
13 results