Brien GL - Search Results

1

Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma.

Brien GL, Remillard D, Shi J, Hemming ML, Chabon J, Wynne K, Dillon ET, Cagney G, Van Mierlo G, Baltissen MP, Vermeulen M, Qi J, Fröhling S, Gray NS, Bradner JE, Vakoc CR, Armstrong SA. Brien GL, et al. Elife. 2018 Nov 15;7:e41305. doi: 10.7554/eLife.41305. Elife. 2018. PMID: 30431433 Free PMC article.

2

Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation.

Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP. Brien GL, et al. Nat Struct Mol Biol. 2012 Dec;19(12):1273-81. doi: 10.1038/nsmb.2449. Epub 2012 Nov 18. Nat Struct Mol Biol. 2012. PMID: 23160351

3

A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.

Brien GL, Healy E, Jerman E, Conway E, Fadda E, O'Donovan D, Krivtsov AV, Rice AM, Kearney CJ, Flaus A, McDade SS, Martin SJ, McLysaght A, O'Connell DJ, Armstrong SA, Bracken AP. Brien GL, et al. Genes Dev. 2015 Nov 1;29(21):2231-43. doi: 10.1101/gad.267930.115. Epub 2015 Oct 22. Genes Dev. 2015. PMID: 26494712 Free PMC article.

4

Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs.

Brien GL, Valerio DG, Armstrong SA. Brien GL, et al. Cancer Cell. 2016 Apr 11;29(4):464-476. doi: 10.1016/j.ccell.2016.03.007. Cancer Cell. 2016. PMID: 27070701 Free PMC article. Review.

5

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

Oliviero G, Brien GL, Waston A, Streubel G, Jerman E, Andrews D, Doyle B, Munawar N, Wynne K, Crean J, Bracken AP, Cagney G. Oliviero G, et al. Among authors: brien gl. Mol Cell Proteomics. 2016 Nov;15(11):3450-3460. doi: 10.1074/mcp.M116.062240. Epub 2016 Sep 15. Mol Cell Proteomics. 2016. PMID: 27634302 Free PMC article.

6

NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.

Xu H, Valerio DG, Eisold ME, Sinha A, Koche RP, Hu W, Chen CW, Chu SH, Brien GL, Park CY, Hsieh JJ, Ernst P, Armstrong SA. Xu H, et al. Among authors: brien gl. Cancer Cell. 2016 Dec 12;30(6):863-878. doi: 10.1016/j.ccell.2016.10.019. Epub 2016 Nov 23. Cancer Cell. 2016. PMID: 27889185 Free PMC article.

7

Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.

Remillard D, Buckley DL, Paulk J, Brien GL, Sonnett M, Seo HS, Dastjerdi S, Wühr M, Dhe-Paganon S, Armstrong SA, Bradner JE. Remillard D, et al. Among authors: brien gl. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743. doi: 10.1002/anie.201611281. Epub 2017 Apr 18. Angew Chem Int Ed Engl. 2017. PMID: 28418626 Free PMC article.

8

Targeting chromatin complexes in fusion protein-driven malignancies.

Brien GL, Stegmaier K, Armstrong SA. Brien GL, et al. Nat Rev Cancer. 2019 May;19(5):255-269. doi: 10.1038/s41568-019-0132-x. Nat Rev Cancer. 2019. PMID: 30962549 Review.

9

A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma.

Lagan E, Gannon D, Silva AJ, Bibawi P, Doherty AM, Nimmo D, McCole R, Monger C, Genesi GL, Vanderlinden A, Innes JA, Jones CLE, Yang L, Chen B, van Mierlo G, Jansen PWTC, Pednekar C, Von Kriegsheim A, Wynne K, Sánchez-Rivera FJ, Soto-Feliciano YM, Carcaboso AM, Vermeulen M, Oliviero G, Chen CW, Phillips RE, Bracken AP, Brien GL. Lagan E, et al. Among authors: brien gl. Mol Cell. 2025 Jun 5;85(11):2110-2127.e7. doi: 10.1016/j.molcel.2025.04.026. Epub 2025 May 21. Mol Cell. 2025. PMID: 40403727 Free article.

10

A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells.

McCole R, Nolan J, Reck DM, Monger C, Rustichelli S, Conway E, Brien GL, Wang C, Deevy O, Neikes HK, Bashore FM, Mooney A, Flavin R, Vandenberghe E, Flanigan SF, Pasini D, Davidovich C, Vermeulen M, James LI, Healy E, Bracken AP. McCole R, et al. Among authors: brien gl. Cell Rep. 2025 Jan 28;44(1):115192. doi: 10.1016/j.celrep.2024.115192. Epub 2025 Jan 11. Cell Rep. 2025. PMID: 39799569 Free article.

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