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5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjørn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, Roth BL, Stevens RC, Liu ZJ. Peng Y, et al. Among authors: yuan s. Cell. 2018 Feb 8;172(4):719-730.e14. doi: 10.1016/j.cell.2018.01.001. Epub 2018 Feb 1. Cell. 2018. PMID: 29398112 Free PMC article.
Exploring a new ligand binding site of G protein-coupled receptors.
Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S. Chan HCS, et al. Among authors: yuan s. Chem Sci. 2018 Jul 13;9(31):6480-6489. doi: 10.1039/c8sc01680a. eCollection 2018 Aug 21. Chem Sci. 2018. PMID: 30310578 Free PMC article.
Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures.
Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ. Hua T, et al. Among authors: yuan s. Cell. 2020 Feb 20;180(4):655-665.e18. doi: 10.1016/j.cell.2020.01.008. Epub 2020 Jan 30. Cell. 2020. PMID: 32004463 Free PMC article.
Enhancing the Signaling of GPCRs via Orthosteric Ions.
Chan HCS, Xu Y, Tan L, Vogel H, Cheng J, Wu D, Yuan S. Chan HCS, et al. Among authors: yuan s. ACS Cent Sci. 2020 Feb 26;6(2):274-282. doi: 10.1021/acscentsci.9b01247. Epub 2020 Jan 23. ACS Cent Sci. 2020. PMID: 32123746 Free PMC article.
Computational drug development for membrane protein targets.
Li H, Sun X, Cui W, Xu M, Dong J, Ekundayo BE, Ni D, Rao Z, Guo L, Stahlberg H, Yuan S, Vogel H. Li H, et al. Among authors: yuan s. Nat Biotechnol. 2024 Feb;42(2):229-242. doi: 10.1038/s41587-023-01987-2. Epub 2024 Feb 15. Nat Biotechnol. 2024. PMID: 38361054 Review.
9,270 results