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262 results

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Page 1
GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression.
Tolosa EJ, Fernandez-Barrena MG, Iguchi E, McCleary-Wheeler AL, Carr RM, Almada LL, Flores LF, Vera RE, Alfonse GW, Marks DL, Hogenson TL, Vrabel AM, Horn IP, Koenig AN, Safgren SL, Sigafoos AN, Erkan M, Romecin-Duran PA, Sarabia Gonzalez A, Zhou B, Javelaud D, Marsaud V, Graham RP, Mauviel A, Elsawa SF, Fernandez-Zapico ME. Tolosa EJ, et al. Among authors: graham rp. Biochem J. 2020 Sep 18;477(17):3131-3145. doi: 10.1042/BCJ20200335. Biochem J. 2020. PMID: 32766732
Gastroblastoma harbors a recurrent somatic MALAT1-GLI1 fusion gene.
Graham RP, Nair AA, Davila JI, Jin L, Jen J, Sukov WR, Wu TT, Appelman HD, Torres-Mora J, Perry KD, Zhang L, Kloft-Nelson SM, Knudson RA, Greipp PT, Folpe AL. Graham RP, et al. Mod Pathol. 2017 Oct;30(10):1443-1452. doi: 10.1038/modpathol.2017.68. Epub 2017 Jul 21. Mod Pathol. 2017. PMID: 28731043 Free article.
The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoter-looping GLI1-STAT3 transcriptional complex.
Carr RM, Romecin Duran PA, Tolosa EJ, Ma C, Oseini AM, Moser CD, Banini BA, Huang J, Asumda F, Dhanasekaran R, Graham RP, Toruner MD, Safgren SL, Almada LL, Wang S, Patnaik MM, Roberts LR, Fernandez-Zapico ME. Carr RM, et al. Among authors: graham rp. J Biol Chem. 2020 Feb 28;295(9):2698-2712. doi: 10.1074/jbc.RA119.011146. Epub 2020 Jan 27. J Biol Chem. 2020. PMID: 31988246 Free PMC article.
Targeting of the Hedgehog/GLI and mTOR pathways in advanced pancreatic cancer, a phase 1 trial of Vismodegib and Sirolimus combination.
Carr RM, Duma N, McCleary-Wheeler AL, Almada LL, Marks DL, Graham RP, Smyrk TC, Lowe V, Borad MJ, Kim G, Johnson GB, Allred JB, Yin J, Lim VS, Bekaii-Saab T, Ma WW, Erlichman C, Adjei AA, Fernandez-Zapico ME. Carr RM, et al. Among authors: graham rp. Pancreatology. 2020 Sep;20(6):1115-1122. doi: 10.1016/j.pan.2020.06.015. Epub 2020 Jul 14. Pancreatology. 2020. PMID: 32778368
Culture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers.
Hogenson TL, Xie H, Phillips WJ, Toruner MD, Li JJ, Horn IP, Kennedy DJ, Almada LL, Marks DL, Carr RM, Toruner M, Sigafoos AN, Koenig-Kappes AN, Olson RL, Tolosa EJ, Zhang C, Li H, Doles JD, Bleeker J, Barrett MT, Boyum JH, Kipp BR, Mahipal A, Hubbard JM, Scheffler Hanson TJ, Petersen GM, Dasari S, Oberg AL, Truty MJ, Graham RP, Levy MJ, Zhu M, Billadeau DD, Adjei AA, Dusetti N, Iovanna JL, Bekaii-Saab TS, Ma WW, Fernandez-Zapico ME. Hogenson TL, et al. Among authors: graham rp. JCI Insight. 2022 Nov 22;7(22):e158060. doi: 10.1172/jci.insight.158060. JCI Insight. 2022. PMID: 36256477 Free PMC article.
KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis.
Sigafoos AN, Tolosa EJ, Carr RM, Fernandez-Barrena MG, Almada LL, Pease DR, Hogenson TL, Raja Arul GL, Mousavi F, Sen S, Vera RE, Marks DL, Flores LF, LaRue-Nolan KC, Wu C, Bamlet WR, Vrabel AM, Sicotte H, Schenk EL, Smyrk TC, Zhang L, Rabe KG, Oberg AL, Zaphiropoulos PG, Chevet E, Graham RP, Hagen CE, di Magliano MP, Elsawa SF, Pin CL, Mao J, McWilliams RR, Fernandez-Zapico ME. Sigafoos AN, et al. Among authors: graham rp. Cancer Res Commun. 2024 Jul 1;4(7):1677-1689. doi: 10.1158/2767-9764.CRC-23-0464. Cancer Res Commun. 2024. PMID: 38896052 Free PMC article.
Emerin is an effector of oncogenic KRAS-driven nuclear dynamics in pancreatic cancer.
Flores LF, Marks DL, Vera RE, Sigafoos AN, Tolosa EJ, Almada LL, Pease DR, Toruner MD, Chang B, Tader BR, LaRue-Nolan KC, Carr RM, Graham RP, Hagen CE, Brown MR, Matveyenko AV, Wilson KL, Dawson DW, Pin CL, Roux KJ, Fernandez-Zapico ME. Flores LF, et al. Among authors: graham rp. JCI Insight. 2025 Jun 10:e187799. doi: 10.1172/jci.insight.187799. Online ahead of print. JCI Insight. 2025. PMID: 40493403 Free article.
Molecular and Immunohistochemical Analysis of Mucinous Cystic Neoplasm of the Liver.
Van Treeck BJ, Lotfalla M, Czeczok TW, Mounajjed T, Moreira RK, Allende DS, Reid MD, Naini BV, Westerhoff M, Adsay NV, Kerr SE, I Ilyas S, Smoot RL, Liu Y, Davila J, Graham RP. Van Treeck BJ, et al. Among authors: graham rp. Am J Clin Pathol. 2020 Nov 4;154(6):837-847. doi: 10.1093/ajcp/aqaa115. Am J Clin Pathol. 2020. PMID: 32880620 Free PMC article.
262 results