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A high throughput screen for TMPRSS2 expression identifies FDA-approved and clinically advanced compounds that can limit SARS-CoV-2 entry.
Chen Y, Lear TB, Evankovich JW, Larsen MB, Lin B, Alfaras I, Kennerdell JR, Salminen L, Camarco DP, Lockwood KC, Liu J, Myerburg MM, McDyer JF, Liu Y, Finkel T, Chen BB. Chen Y, et al. Among authors: lin b. Res Sq [Preprint]. 2020 Aug 14:rs.3.rs-48659. doi: 10.21203/rs.3.rs-48659/v1. Res Sq. 2020. Update in: Nat Commun. 2021 Jun 23;12(1):3907. doi: 10.1038/s41467-021-24156-y. PMID: 32818215 Free PMC article. Updated. Preprint.
A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance.
Liu Y, Jurczak MJ, Lear TB, Lin B, Larsen MB, Kennerdell JR, Chen Y, Huckestein BR, Nguyen MK, Tuncer F, Jiang Y, Monga SP, O'Donnell CP, Finkel T, Chen BB, Mallampalli RK. Liu Y, et al. Among authors: lin b. Nat Chem Biol. 2021 Mar;17(3):298-306. doi: 10.1038/s41589-020-00723-0. Epub 2021 Jan 25. Nat Chem Biol. 2021. PMID: 33495648 Free PMC article.
Modulation of lysosomal function as a therapeutic approach for coronaviral infections.
Liu Y, Lear T, Larsen M, Lin B, Cao Q, Alfaras I, Kennerdell J, Salminen L, Camarco D, Lockwood K, Ma J, Liu J, Tan J, Myerburg M, Chen Y, St Croix C, Sekine Y, Evankovich J, Finkel T, Chen B. Liu Y, et al. Among authors: lin b. Res Sq [Preprint]. 2021 Apr 23:rs.3.rs-419305. doi: 10.21203/rs.3.rs-419305/v1. Res Sq. 2021. PMID: 34013250 Free PMC article. Preprint.
Inhibition of virally induced TFEB proteasomal degradation as a host-centric therapeutic approach for coronaviral infection.
Lear TB, Larsen MB, Lin B, Treat BR, Cao Q, Boudreau ÁN, Lockwood KC, Alfaras I, Kennerdell JR, Salminen L, Camarco DP, Tong Y, Ma J, Liu J, Tan JX, Tuncer F, Villandre JJ, Hertzel L, Myerburg MM, Chen Y, St Croix C, Sekine Y, Evankovich JW, Barratt-Boyes SM, Finkel T, Chen BB, Liu Y. Lear TB, et al. Among authors: lin b. Sci Adv. 2025 Jun 6;11(23):eadv4033. doi: 10.1126/sciadv.adv4033. Epub 2025 Jun 4. Sci Adv. 2025. PMID: 40465712 Free PMC article.
Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma.
Lin B, Shelton AK, Smithberger E, Ziebro J, Skinner KR, Bash RE, Kirkman R, Stamper A, Butler M, Flores A, Angus SP, East MP, Cloughesy TF, Nathanson DA, Berens ME, Sarkaria JN, Binder ZA, O'Rourke DM, Howton TC, Lasseigne BN, Willey CD, Johnson GL, Hjelmeland AB, Furnari FB, Miller CR. Lin B, et al. Acta Neuropathol Commun. 2025 Jun 28;13(1):143. doi: 10.1186/s40478-025-02068-y. Acta Neuropathol Commun. 2025. PMID: 40581663
7,288 results