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Safety, pharmacokinetics and pharmacodynamics of SBT-020 in patients with early stage Huntington's disease, a 2-part study.
van Diemen MPJ, Hart EP, Abbruscato A, Mead L, van Beelen I, Bergheanu SC, Hameeteman PW, Coppen E, Winder JY, Moerland M, Kan H, van der Grond J, Webb A, Roos RAC, Groeneveld GJ. van Diemen MPJ, et al. Among authors: groeneveld gj. Br J Clin Pharmacol. 2021 May;87(5):2290-2302. doi: 10.1111/bcp.14656. Epub 2020 Dec 29. Br J Clin Pharmacol. 2021. PMID: 33197078 Free PMC article. Clinical Trial.
The use of biomarkers in human pharmacology (Phase I) studies.
Cohen AF, Burggraaf J, van Gerven JM, Moerland M, Groeneveld GJ. Cohen AF, et al. Among authors: groeneveld gj. Annu Rev Pharmacol Toxicol. 2015;55:55-74. doi: 10.1146/annurev-pharmtox-011613-135918. Epub 2014 Oct 6. Annu Rev Pharmacol Toxicol. 2015. PMID: 25292425 Review.
Pharmacokinetics and pharmacodynamics of oral mecamylamine - development of a nicotinic acetylcholine receptor antagonist cognitive challenge test using modelling and simulation.
Alvarez-Jimenez R, Baakman AC, Stevens J, Goulooze SC, Hart EP, Rissmann R, van Gerven JM, Groeneveld GJ. Alvarez-Jimenez R, et al. Among authors: groeneveld gj. J Psychopharmacol. 2017 Feb;31(2):192-203. doi: 10.1177/0269881116681417. Epub 2016 Dec 9. J Psychopharmacol. 2017. PMID: 27927703
An anti-nicotinic cognitive challenge model using mecamylamine in comparison with the anti-muscarinic cognitive challenge using scopolamine.
Baakman AC, Alvarez-Jimenez R, Rissmann R, Klaassen ES, Stevens J, Goulooze SC, den Burger JCG, Swart EL, van Gerven JMA, Groeneveld GJ. Baakman AC, et al. Among authors: groeneveld gj. Br J Clin Pharmacol. 2017 Aug;83(8):1676-1687. doi: 10.1111/bcp.13268. Epub 2017 Apr 8. Br J Clin Pharmacol. 2017. PMID: 28217868 Free PMC article. Clinical Trial.
156 results