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SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma.
Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, Cardarelli L, Troyanskaya O, Sidhu SS, Roybal KT, Okada H, Lim WA. Choe JH, et al. Among authors: goretsky ye. Sci Transl Med. 2021 Apr 28;13(591):eabe7378. doi: 10.1126/scitranslmed.abe7378. Sci Transl Med. 2021. PMID: 33910979 Free PMC article.
Tumor antigens in glioma.
Nejo T, Yamamichi A, Almeida ND, Goretsky YE, Okada H. Nejo T, et al. Among authors: goretsky ye. Semin Immunol. 2020 Feb;47:101385. doi: 10.1016/j.smim.2020.101385. Epub 2020 Feb 6. Semin Immunol. 2020. PMID: 32037183 Review.
RHOA Loss of Function Impairs the IFNγ Response and Promotes CD19 Antigen Escape to Drive CAR-T Resistance in Diffuse Large B-cell Lymphoma.
Newsam AD, Ziccheddu B, Gowda Saralamma VV, Coughlin CA, Goretsky YE, Youssfi AA, Russo MV, Gallego NC, Fattakhov N, Coffey DG, Tsai DE, Carmona-Berrio D, Suissa DM, Manara P, Sondhi AK, Roberts ER, Sheffield-Veney I, Spiegel JY, Amador C, Alderuccio JP, Bilbao D, Jain MD, Maura F, Locke FL, Schatz JH. Newsam AD, et al. Among authors: goretsky ye. bioRxiv [Preprint]. 2025 Mar 4:2025.02.27.640687. doi: 10.1101/2025.02.27.640687. bioRxiv. 2025. PMID: 40093149 Free PMC article. Preprint.