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Page 1
CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML.
Vinyard ME, Su C, Siegenfeld AP, Waterbury AL, Freedy AM, Gosavi PM, Park Y, Kwan EE, Senzer BD, Doench JG, Bauer DE, Pinello L, Liau BB. Vinyard ME, et al. Nat Chem Biol. 2019 May;15(5):529-539. doi: 10.1038/s41589-019-0263-0. Epub 2019 Apr 15. Nat Chem Biol. 2019. PMID: 30992567 Free PMC article.
SIMBA: single-cell embedding along with features.
Chen H, Ryu J, Vinyard ME, Lerer A, Pinello L. Chen H, et al. Among authors: vinyard me. Nat Methods. 2024 Jun;21(6):1003-1013. doi: 10.1038/s41592-023-01899-8. Epub 2023 May 29. Nat Methods. 2024. PMID: 37248389 Free PMC article.
Integrative dissection of gene regulatory elements at base resolution.
Chen Z, Javed N, Moore M, Wu J, Sun G, Vinyard M, Collins A, Pinello L, Najm FJ, Bernstein BE. Chen Z, et al. Among authors: vinyard m. Cell Genom. 2023 Apr 28;3(6):100318. doi: 10.1016/j.xgen.2023.100318. eCollection 2023 Jun 14. Cell Genom. 2023. PMID: 37388913 Free PMC article.
Defining and benchmarking open problems in single-cell analysis.
Luecken MD, Gigante S, Burkhardt DB, Cannoodt R, Strobl DC, Markov NS, Zappia L, Palla G, Lewis W, Dimitrov D, Vinyard ME, Magruder DS, Mueller MF, Andersson A, Dann E, Qin Q, Otto DJ, Klein M, Botvinnik OB, Deconinck L, Waldrant K, Yasa SN, Szałata A, Benz A, Li Z; Open Problems Jamboree Members; Bloom JM, Pisco AO, Saez-Rodriguez J, Wulsin D, Pinello L, Saeys Y, Theis FJ, Krishnaswamy S. Luecken MD, et al. Among authors: vinyard me. Nat Biotechnol. 2025 Jul 1. doi: 10.1038/s41587-025-02694-w. Online ahead of print. Nat Biotechnol. 2025. PMID: 40595413 No abstract available.
A Molecular Glue Approach to Control the Half-Life of CRISPR-Based Technologies.
Sreekanth V, Jan M, Zhao KT, Lim D, Siriwongsup S, Davis JR, McConkey M, Kovalcik V, Barkal S, Law BK, Fife J, Tian N, Vinyard ME, Becerra B, Kampmann M, Sherwood RI, Pinello L, Liu DR, Ebert BL, Choudhary A. Sreekanth V, et al. Among authors: vinyard me. J Am Chem Soc. 2025 Jun 30. doi: 10.1021/jacs.5c06230. Online ahead of print. J Am Chem Soc. 2025. PMID: 40586242
An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing.
Waterbury AL, Kwok HS, Lee C, Narducci DN, Freedy AM, Su C, Raval S, Reiter AH, Hawkins W, Lee K, Li J, Hoenig SM, Vinyard ME, Cole PA, Hansen AS, Carr SA, Papanastasiou M, Liau BB. Waterbury AL, et al. Among authors: vinyard me. Mol Cell. 2024 Jun 20;84(12):2238-2254.e11. doi: 10.1016/j.molcel.2024.05.017. Epub 2024 Jun 12. Mol Cell. 2024. PMID: 38870936 Free PMC article.
Defining and benchmarking open problems in single-cell analysis.
Luecken MD, Gigante S, Burkhardt DB, Cannoodt R, Strobl DC, Markov NS, Zappia L, Palla G, Lewis W, Dimitrov D, Vinyard ME, Magruder DS, Andersson A, Dann E, Qin Q, Otto DJ, Klein M, Botvinnik OB, Deconinck L, Waldrant K; Open Problems Jamboree Members; Bloom JM, Pisco AO, Saez-Rodriguez J, Wulsin D, Pinello L, Saeys Y, Theis FJ, Krishnaswamy S. Luecken MD, et al. Among authors: vinyard me. Res Sq [Preprint]. 2024 Apr 4:rs.3.rs-4181617. doi: 10.21203/rs.3.rs-4181617/v1. Res Sq. 2024. PMID: 38645152 Free PMC article. Preprint.
12 results