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RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis.
Carr RM, Vorobyev D, Lasho T, Marks DL, Tolosa EJ, Vedder A, Almada LL, Yurcheko A, Padioleau I, Alver B, Coltro G, Binder M, Safgren SL, Horn I, You X, Solary E, Balasis ME, Berger K, Hiebert J, Witzig T, Buradkar A, Graf T, Valent P, Mangaonkar AA, Robertson KD, Howard MT, Kaufmann SH, Pin C, Fernandez-Zapico ME, Geissler K, Droin N, Padron E, Zhang J, Nikolaev S, Patnaik MM. Carr RM, et al. Among authors: almada ll. Nat Commun. 2021 May 18;12(1):2901. doi: 10.1038/s41467-021-23186-w. Nat Commun. 2021. PMID: 34006870 Free PMC article.
The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner.
Nye MD, Almada LL, Fernandez-Barrena MG, Marks DL, Elsawa SF, Vrabel A, Tolosa EJ, Ellenrieder V, Fernandez-Zapico ME. Nye MD, et al. Among authors: almada ll. J Biol Chem. 2014 May 30;289(22):15495-506. doi: 10.1074/jbc.M113.545194. Epub 2014 Apr 16. J Biol Chem. 2014. PMID: 24739390 Free PMC article.
Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism.
Bednar F, Schofield HK, Collins MA, Yan W, Zhang Y, Shyam N, Eberle JA, Almada LL, Olive KP, Bardeesy N, Fernandez-Zapico ME, Nakada D, Simeone DM, Morrison SJ, Pasca di Magliano M. Bednar F, et al. Among authors: almada ll. Carcinogenesis. 2015 Jul;36(7):730-8. doi: 10.1093/carcin/bgv058. Epub 2015 May 4. Carcinogenesis. 2015. PMID: 25939753 Free PMC article.
62 results