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Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer.
Yang Y, Badura ML, O'Leary PC, Delavan HM, Robinson TM, Egusa EA, Zhong X, Swinderman JT, Li H, Zhang M, Kim M, Ashworth A, Feng FY, Chou J, Yang L. Yang Y, et al. Among authors: swinderman jt. Nat Cancer. 2024 Dec;5(12):1885-1901. doi: 10.1038/s43018-024-00848-4. Epub 2024 Nov 18. Nat Cancer. 2024. PMID: 39558146 Free PMC article.
Large tandem duplications in cancer result from transcription and DNA replication collisions.
Yang Y, Badura ML, O'Leary PC, Delavan HM, Robinson TM, Egusa EA, Zhong X, Swinderman JT, Li H, Zhang M, Kim M, Ashworth A, Feng FY, Chou J, Yang L. Yang Y, et al. Among authors: swinderman jt. medRxiv [Preprint]. 2024 Jan 10:2023.05.17.23290140. doi: 10.1101/2023.05.17.23290140. medRxiv. 2024. Update in: Nat Cancer. 2024 Dec;5(12):1885-1901. doi: 10.1038/s43018-024-00848-4. PMID: 38260434 Free PMC article. Updated. Preprint.
ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway in breast cancer.
Wang S, Böhnert V, Joseph AJ, Sudaryo V, Skariah G, Swinderman JT, Yu FB, Subramanyam V, Wolf DM, Lyu X, Gilbert LA, Van't Veer LJ, Goodarzi H, Li L. Wang S, et al. Among authors: swinderman jt. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2313693120. doi: 10.1073/pnas.2313693120. Epub 2023 Dec 20. Proc Natl Acad Sci U S A. 2023. PMID: 38117852 Free PMC article.
An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer.
Das R, Sjöström M, Shrestha R, Yogodzinski C, Egusa EA, Chesner LN, Chen WS, Chou J, Dang DK, Swinderman JT, Ge A, Hua JT, Kabir S, Quigley DA, Small EJ, Ashworth A, Feng FY, Gilbert LA. Das R, et al. Among authors: swinderman jt. Nat Commun. 2021 Jul 29;12(1):4601. doi: 10.1038/s41467-021-24919-7. Nat Commun. 2021. PMID: 34326322 Free PMC article.