Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer.
Mahat DB, Kumra H, Castro SA, Metcalf E, Nguyen K, Morisue R, Ho WW, Chen I, Sullivan B, Yim LH, Singh A, Fu J, Waterton SK, Cheng YC, Moiso E, Chauhan VP, Silva HM, Spranger S, Jain RK, Sharp PA.
Mahat DB, et al. Among authors: cheng yc.
Immunity. 2025 Jun 25:S1074-7613(25)00274-2. doi: 10.1016/j.immuni.2025.06.005. Online ahead of print.
Immunity. 2025.
PMID: 40592342