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CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping.
Naert T, Tulkens D, Van Nieuwenhuysen T, Przybyl J, Demuynck S, van de Rijn M, Al-Jazrawe M, Alman BA, Coucke PJ, De Leeneer K, Vanhove C, Savvides SN, Creytens D, Vleminckx K. Naert T, et al. Among authors: savvides sn. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2115116118. doi: 10.1073/pnas.2115116118. Proc Natl Acad Sci U S A. 2021. PMID: 34789568 Free PMC article.
Small-angle X-ray scattering of engineered antigen-binding fragments: the case of glycosylated Fab from the Mannitou IgM antibody.
Semwal S, Karamolegkou M, Flament S, Raouraoua N, Verstraete K, Thureau A, Wien F, Bray F, Savvides SN, Bouckaert J. Semwal S, et al. Among authors: savvides sn. Acta Crystallogr F Struct Biol Commun. 2025 Jan 1;81(Pt 1):19-29. doi: 10.1107/S2053230X24012159. Epub 2025 Jan 1. Acta Crystallogr F Struct Biol Commun. 2025. PMID: 39718025 Free PMC article.
Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting.
Pannecoucke E, Van Trimpont M, Desmet J, Pieters T, Reunes L, Demoen L, Vuylsteke M, Loverix S, Vandenbroucke K, Alard P, Henderikx P, Deroo S, Baatz F, Lorent E, Thiolloy S, Somers K, McGrath Y, Van Vlierberghe P, Lasters I, Savvides SN. Pannecoucke E, et al. Among authors: savvides sn. Sci Adv. 2021 Mar 26;7(13):eabe1682. doi: 10.1126/sciadv.abe1682. Print 2021 Mar. Sci Adv. 2021. PMID: 33771865 Free PMC article.
Improving de novo protein binder design with deep learning.
Bennett NR, Coventry B, Goreshnik I, Huang B, Allen A, Vafeados D, Peng YP, Dauparas J, Baek M, Stewart L, DiMaio F, De Munck S, Savvides SN, Baker D. Bennett NR, et al. Among authors: savvides sn. Nat Commun. 2023 May 6;14(1):2625. doi: 10.1038/s41467-023-38328-5. Nat Commun. 2023. PMID: 37149653 Free PMC article.
Design of protein-binding proteins from the target structure alone.
Cao L, Coventry B, Goreshnik I, Huang B, Sheffler W, Park JS, Jude KM, Marković I, Kadam RU, Verschueren KHG, Verstraete K, Walsh STR, Bennett N, Phal A, Yang A, Kozodoy L, DeWitt M, Picton L, Miller L, Strauch EM, DeBouver ND, Pires A, Bera AK, Halabiya S, Hammerson B, Yang W, Bernard S, Stewart L, Wilson IA, Ruohola-Baker H, Schlessinger J, Lee S, Savvides SN, Garcia KC, Baker D. Cao L, et al. Among authors: savvides sn. Nature. 2022 May;605(7910):551-560. doi: 10.1038/s41586-022-04654-9. Epub 2022 Mar 24. Nature. 2022. PMID: 35332283 Free PMC article.
Expression, purification, crystallization and preliminary X-ray crystallographic studies of a cold-adapted aspartate carbamoyltransferase from Moritella profunda.
De Vos D, Hulpiau P, Vergauwen B, Savvides SN, Van Beeumen J. De Vos D, et al. Among authors: savvides sn. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt 3):279-81. doi: 10.1107/S174430910500285X. Epub 2005 Feb 12. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID: 16511017 Free PMC article.
Expression, purification, crystallization and preliminary crystallographic analysis of a stand-alone RAM domain with hydrolytic activity from the hyperthermophile Pyrococcus furiosus.
Agapay RC, Savvides SN, Van Driessche G, Devreese B, Van Beeumen J, Jongejan JA, Hagen WR. Agapay RC, et al. Among authors: savvides sn. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 1;61(Pt 10):914-6. doi: 10.1107/S1744309105028393. Epub 2005 Sep 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID: 16511194 Free PMC article.
141 results