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Page 1
LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade.
Hickman A, Koetsier J, Kurtanich T, Nielsen MC, Winn G, Wang Y, Bentebibel SE, Shi L, Punt S, Williams L, Haymaker C, Chesson CB, Fa'ak F, Dominguez AL, Jones R, Kuiatse I, Caivano AR, Khounlo S, Warier ND, Marathi U, Market RV, Biediger RJ, Craft JW Jr, Hwu P, Davies MA, Woodside DG, Vanderslice P, Diab A, Overwijk WW, Hailemichael Y. Hickman A, et al. Among authors: kurtanich t. J Clin Invest. 2022 Jul 1;132(13):e154152. doi: 10.1172/JCI154152. J Clin Invest. 2022. PMID: 35552271 Free PMC article.
Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity.
Kang S, Mansurov A, Kurtanich T, Chun HR, Slezak AJ, Volpatti LR, Chang K, Wang T, Alpar AT, Refvik KC, Hansen OI, Borjas GJ, Shim HN, Hultgren KT, Gomes S, Solanki A, Ishihara J, Swartz MA, Hubbell JA. Kang S, et al. Among authors: kurtanich t. Sci Adv. 2023 Dec;9(48):eadh9879. doi: 10.1126/sciadv.adh9879. Epub 2023 Nov 29. Sci Adv. 2023. PMID: 38019919 Free PMC article.
Liver-targeted allergen immunotherapy rapidly and safely induces antigen-specific tolerance to treat allergic airway disease in mice.
Gómez Medellín JE, Ung TWM, Wang T, Chang K, Cassano A, Kurtanich T, Reda JW, Shema KE, Stanic N, Slezak AJ, Vuong I, Chen B, Cao S, Alegre ML, Swartz MA, Hubbell JA. Gómez Medellín JE, et al. Among authors: kurtanich t. Sci Transl Med. 2025 Apr 16;17(794):eadl0406. doi: 10.1126/scitranslmed.adl0406. Epub 2025 Apr 16. Sci Transl Med. 2025. PMID: 40238914
Engineered GM-CSF polarizes protumorigenic tumor-associated macrophages to an antitumorigenic phenotype and potently synergizes with IL-12 immunotherapy.
Kang S, Mansurov A, Kurtanich T, Chun HR, Slezak AJ, Volpatti LR, Chang K, Wang T, Alpar AT, Refvik KC, Hansen OI, Borjas GJ, Berg BTK, Shim HN, Hultgren KT, Gomes S, Wang Y, Solanki A, Ishihara J, Swartz MA, Hubbell JA. Kang S, et al. Among authors: kurtanich t. J Immunother Cancer. 2024 Dec 22;12(12):e009541. doi: 10.1136/jitc-2024-009541. J Immunother Cancer. 2024. PMID: 39794939 Free PMC article.
Membrane-localized neoantigens predict the efficacy of cancer immunotherapy.
Goldberger Z, Hauert S, Chang K, Kurtanich T, Alpar AT, Repond G, Wang Y, Gomes S, Krishnakumar R, Siddarth P, Swartz MA, Hubbell JA, Briquez PS. Goldberger Z, et al. Among authors: kurtanich t. Cell Rep Med. 2023 Aug 15;4(8):101145. doi: 10.1016/j.xcrm.2023.101145. Epub 2023 Aug 7. Cell Rep Med. 2023. PMID: 37552990 Free PMC article.