Liu X - Search Results

1

Structural basis for strychnine activation of human bitter taste receptor TAS2R46.

Xu W, Wu L, Liu S, Liu X, Cao X, Zhou C, Zhang J, Fu Y, Guo Y, Wu Y, Tan Q, Wang L, Liu J, Jiang L, Fan Z, Pei Y, Yu J, Cheng J, Zhao S, Hao X, Liu ZJ, Hua T. Xu W, et al. Among authors: liu zj, liu j, liu x, liu s. Science. 2022 Sep 16;377(6612):1298-1304. doi: 10.1126/science.abo1633. Epub 2022 Sep 15. Science. 2022. PMID: 36108005

2

Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN.

Sun N, Qin YJ, Xu C, Xia T, Du ZW, Zheng LP, Li AA, Meng F, Zhang Y, Zhang J, Liu X, Li TY, Zhu DY, Zhou QG. Sun N, et al. Among authors: liu x. Science. 2022 Oct 28;378(6618):390-398. doi: 10.1126/science.abo3566. Epub 2022 Oct 27. Science. 2022. PMID: 36302033

3

Cryo-EM structures of PI3Kα reveal conformational changes during inhibition and activation.

Liu X, Yang S, Hart JR, Xu Y, Zou X, Zhang H, Zhou Q, Xia T, Zhang Y, Yang D, Wang MW, Vogt PK. Liu X, et al. Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2109327118. doi: 10.1073/pnas.2109327118. Proc Natl Acad Sci U S A. 2021. PMID: 34725156 Free PMC article.

4

Beating crystallization in glass-forming metals by millisecond heating and processing.

Johnson WL, Kaltenboeck G, Demetriou MD, Schramm JP, Liu X, Samwer K, Kim CP, Hofmann DC. Johnson WL, et al. Among authors: liu x. Science. 2011 May 13;332(6031):828-33. doi: 10.1126/science.1201362. Science. 2011. PMID: 21566189

5

Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα.

Liu X, Zhou Q, Hart JR, Xu Y, Yang S, Yang D, Vogt PK, Wang MW. Liu X, et al. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2215621119. doi: 10.1073/pnas.2215621119. Epub 2022 Nov 7. Proc Natl Acad Sci U S A. 2022. PMID: 36343266 Free PMC article.

6

Nanobodies and chemical cross-links advance the structural and functional analysis of PI3Kα.

Hart JR, Liu X, Pan C, Liang A, Ueno L, Xu Y, Quezada A, Zou X, Yang S, Zhou Q, Schoonooghe S, Hassanzadeh-Ghassabeh G, Xia T, Shui W, Yang D, Vogt PK, Wang MW. Hart JR, et al. Among authors: liu x. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2210769119. doi: 10.1073/pnas.2210769119. Epub 2022 Sep 12. Proc Natl Acad Sci U S A. 2022. PMID: 36095215 Free PMC article.

7

Structural insights into the interaction of three Y-shaped ligands with PI3Kα.

Zhou Q, Liu X, Neri D, Li W, Favalli N, Bassi G, Yang S, Yang D, Vogt PK, Wang MW. Zhou Q, et al. Among authors: liu x. Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2304071120. doi: 10.1073/pnas.2304071120. Epub 2023 Aug 16. Proc Natl Acad Sci U S A. 2023. PMID: 37585458 Free PMC article.

8

An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9.

Wang YZ, Liu X, Way G, Madarha V, Zhou QT, Yang DH, Liao JY, Wang MW. Wang YZ, et al. Among authors: liu x. Acta Pharmacol Sin. 2020 Nov;41(11):1497-1506. doi: 10.1038/s41401-020-0405-7. Epub 2020 Apr 27. Acta Pharmacol Sin. 2020. PMID: 32341466 Free PMC article.

9

Visualizing the dual interaction of calcineurin with PI4KA and FAM126A.

Zhou Q, Liu X, Wang MW. Zhou Q, et al. Among authors: liu x. Structure. 2024 Nov 7;32(11):1852-1854. doi: 10.1016/j.str.2024.10.010. Structure. 2024. PMID: 39515303

10

A First-in-Human Study of Givastomig, a CLDN18.2 and 4-1BB Bispecific Antibody, as Monotherapy in Patients with CLDN18.2-Positive Advanced or Metastatic Solid Tumors.

Ku G, Shen L, Dayyani F, Kratz J, Liang X, Liu F, Wang Z, Feller L, Girda E, Pan H, Kim S, Deng Y, Deng T, Liu T, Powderly J, Spencer K, Schneider R, Berlin J, Xu CC, Ahlers CM, Liu X, Chung JK, Sabbatini P, Park J, Lim Y, Jeon J, Meng Y, Klempner SJ. Ku G, et al. Among authors: liu x. Clin Cancer Res. 2025 Jun 30. doi: 10.1158/1078-0432.CCR-24-4280. Online ahead of print. Clin Cancer Res. 2025. PMID: 40586719

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