Gao AW - Search Results

1

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.

Bou Sleiman M, Roy S, Gao AW, Sadler MC, von Alvensleben GVG, Li H, Sen S, Harrison DE, Nelson JF, Strong R, Miller RA, Kutalik Z, Williams RW, Auwerx J. Bou Sleiman M, et al. Among authors: gao aw. Science. 2022 Sep 30;377(6614):eabo3191. doi: 10.1126/science.abo3191. Epub 2022 Sep 30. Science. 2022. PMID: 36173858 Free PMC article.

2

Identifying gene function and module connections by the integration of multispecies expression compendia.

Li H, Rukina D, David FPA, Li TY, Oh CM, Gao AW, Katsyuba E, Bou Sleiman M, Komljenovic A, Huang Q, Williams RW, Robinson-Rechavi M, Schoonjans K, Morgenthaler S, Auwerx J. Li H, et al. Among authors: gao aw. Genome Res. 2019 Dec;29(12):2034-2045. doi: 10.1101/gr.251983.119. Epub 2019 Nov 21. Genome Res. 2019. PMID: 31754022 Free PMC article.

3

The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress.

Li TY, Sleiman MB, Li H, Gao AW, Mottis A, Bachmann AM, El Alam G, Li X, Goeminne LJE, Schoonjans K, Auwerx J. Li TY, et al. Among authors: gao aw. Nat Aging. 2021 Feb;1(2):165-178. doi: 10.1038/s43587-020-00025-z. Epub 2021 Feb 8. Nat Aging. 2021. PMID: 33718883 Free PMC article.

4

Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains.

Gao AW, El Alam G, Lalou A, Li TY, Molenaars M, Zhu Y, Overmyer KA, Shishkova E, Hof K, Bou Sleiman M, Houtkooper RH, Coon JJ, Auwerx J. Gao AW, et al. iScience. 2022 Jan 5;25(2):103734. doi: 10.1016/j.isci.2022.103734. eCollection 2022 Feb 18. iScience. 2022. PMID: 35118355 Free PMC article.

5

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans.

Li TY, Gao AW, Li X, Li H, Liu YJ, Lalou A, Neelagandan N, Naef F, Schoonjans K, Auwerx J. Li TY, et al. Among authors: gao aw. J Cell Biol. 2023 Jan 2;222(1):e202205045. doi: 10.1083/jcb.202205045. Epub 2022 Oct 31. J Cell Biol. 2023. PMID: 36314986 Free PMC article.

6

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation.

Li TY, Wang Q, Gao AW, Li X, Sun Y, Mottis A, Shong M, Auwerx J. Li TY, et al. Among authors: gao aw. Cell Discov. 2023 Sep 7;9(1):92. doi: 10.1038/s41421-023-00589-1. Cell Discov. 2023. PMID: 37679337 Free PMC article.

7

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan.

Gao AW, El Alam G, Zhu Y, Li W, Sulc J, Li X, Katsyuba E, Li TY, Overmyer KA, Lalou A, Mouchiroud L, Sleiman MB, Cornaglia M, Morel JD, Houtkooper RH, Coon JJ, Auwerx J. Gao AW, et al. Cell Rep. 2024 Oct 22;43(10):114836. doi: 10.1016/j.celrep.2024.114836. Epub 2024 Oct 4. Cell Rep. 2024. PMID: 39368088 Free PMC article.

8

A lysosomal surveillance response to stress extends healthspan.

Li TY, Gao AW, Yang R, Sun Y, Lei Y, Li X, Chen L, Liu YJ, Arey RN, Morales K, Liu RB, Wang W, Zhou A, Zhao TJ, Li W, Lalou A, Wang Q, Lima T, Houtkooper RH, Auwerx J. Li TY, et al. Among authors: gao aw. Nat Cell Biol. 2025 Jun 26. doi: 10.1038/s41556-025-01693-y. Online ahead of print. Nat Cell Biol. 2025. PMID: 40571723

9

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion.

Liu YJ, Janssens GE, McIntyre RL, Molenaars M, Kamble R, Gao AW, Jongejan A, Weeghel MV, MacInnes AW, Houtkooper RH. Liu YJ, et al. Among authors: gao aw. PLoS Genet. 2019 Mar 7;15(3):e1007633. doi: 10.1371/journal.pgen.1007633. eCollection 2019 Mar. PLoS Genet. 2019. PMID: 30845140 Free PMC article.

10

Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans.

Liu YJ, Gao AW, Smith RL, Janssens GE, Panneman DM, Jongejan A, van Weeghel M, Vaz FM, Silvestrini MJ, Lapierre LR, MacInnes AW, Houtkooper RH. Liu YJ, et al. Among authors: gao aw. Sci Rep. 2022 Mar 1;12(1):3350. doi: 10.1038/s41598-022-07397-9. Sci Rep. 2022. PMID: 35233004 Free PMC article.

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