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Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically "actionable" signalling axis in triple negative breast cancer.
Yang X, Ma X, Zhao T, Croucher DR, Nguyen EV, Clark KC, Hu C, Latham SL, Bayly-Jones C, Nguyen VCB, Budnar S, Shin S, Nguyen LK, Cotton TR, Chueh AC, Sian TCLK, Stratton MM, Ellisdon AM, Daly RJ. Yang X, et al. Among authors: clark kc. bioRxiv [Preprint]. 2024 Nov 22:2024.02.14.580406. doi: 10.1101/2024.02.14.580406. bioRxiv. 2024. Update in: Nat Commun. 2025 Feb 22;16(1):1871. doi: 10.1038/s41467-025-57046-8. PMID: 38405732 Free PMC article. Updated. Preprint.
Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer.
Yang X, Ma X, Zhao T, Croucher DR, Nguyen EV, Clark KC, Hu C, Latham SL, Bayly-Jones C, Nguyen BV, Budnar S, Shin SY, Nguyen LK, Cotton TR, Chüeh AC, Lim Kam Sian TCC, Stratton MM, Ellisdon AM, Daly RJ. Yang X, et al. Among authors: clark kc. Nat Commun. 2025 Feb 22;16(1):1871. doi: 10.1038/s41467-025-57046-8. Nat Commun. 2025. PMID: 39984440 Free PMC article.
Age-related mesenchymal stromal cell senescence is associated with progression from MGUS to multiple myeloma.
Plakhova N, Panagopoulos V, Cantley MD, Trainor LJ, Hewett DR, Clark KC, Gardiner J, Yong A, Lee C, Horvath N, Croucher PI, Cakouros D, Stewart SA, Gronthos S, Zannettino ACW, Mrozik KM, Vandyke K. Plakhova N, et al. Among authors: clark kc. Leukemia. 2025 Jun;39(6):1464-1475. doi: 10.1038/s41375-025-02621-7. Epub 2025 Apr 22. Leukemia. 2025. PMID: 40263435 Free PMC article.
69 results