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SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant.
Guo H, Yu X, Liu Y, Paik DT, Justesen JM, Chandy M, Jahng JWS, Zhang T, Wu W, Rwere F, Zhao SR, Pokhrel S, Shivnaraine RV, Mukherjee S, Simon DJ, Manhas A, Zhang A, Chen CH, Rivas MA, Gross ER, Mochly-Rosen D, Wu JC. Guo H, et al. Among authors: zhang a, zhang t. Sci Transl Med. 2023 Jan 25;15(680):eabp9952. doi: 10.1126/scitranslmed.abp9952. Epub 2023 Jan 25. Sci Transl Med. 2023. PMID: 36696485 Free PMC article.
An FDA-approved drug structurally and phenotypically corrects the K210del mutation in genetic cardiomyopathy models.
Wang P, Ahmed MS, Nguyen NUN, Menendez-Montes I, Hsu CC, Farag AB, Thet S, Lam NT, Wansapura JP, Crossley E, Ma N, Zhao SR, Zhang T, Morimoto S, Singh R, Elhelaly W, Tassin TC, Cardoso AC, Williams NS, Pointer HL, Elliott DA, McNamara JW, Watt KI, Porrello ER, Sadayappan S, Sadek HA. Wang P, et al. Among authors: zhang t. J Clin Invest. 2025 Feb 17;135(4):e174081. doi: 10.1172/JCI174081. J Clin Invest. 2025. PMID: 39959972 Free PMC article.
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