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751 results

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Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease.
Chou CC, Vest R, Prado MA, Wilson-Grady J, Paulo JA, Shibuya Y, Moran-Losada P, Lee TT, Luo J, Gygi SP, Kelly JW, Finley D, Wernig M, Wyss-Coray T, Frydman J. Chou CC, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2025 Jan 13:2023.03.27.534444. doi: 10.1101/2023.03.27.534444. bioRxiv. 2025. Update in: Nat Cell Biol. 2025 Apr;27(4):619-632. doi: 10.1038/s41556-025-01623-y. PMID: 37034684 Free PMC article. Updated. Preprint.
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.
Mitchell W, Goeminne LJE, Tyshkovskiy A, Zhang S, Chen JY, Paulo JA, Pierce KA, Choy AH, Clish CB, Gygi SP, Gladyshev VN. Mitchell W, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2023 Nov 27:2023.06.30.546730. doi: 10.1101/2023.06.30.546730. bioRxiv. 2023. Update in: Elife. 2024 Mar 22;12:RP90579. doi: 10.7554/eLife.90579. PMID: 37425825 Free PMC article. Updated. Preprint.
The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway.
Chen H, Ferguson CJ, Mitchell DC, Titus A, Paulo JA, Hwang A, Lin TH, Yano H, Gu W, Song SK, Yuede CM, Gygi SP, Bonni A, Kim AH. Chen H, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2024 Jun 29:2023.10.24.563880. doi: 10.1101/2023.10.24.563880. bioRxiv. 2024. Update in: Cell Rep. 2025 Feb 25;44(2):115231. doi: 10.1016/j.celrep.2025.115231. PMID: 37961719 Free PMC article. Updated. Preprint.
751 results