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Physiologically-based pharmacokinetic modeling of pantoprazole to evaluate the role of CYP2C19 genetic variation and obesity in the pediatric population.
Thompson EJ, Jeong A, Helfer VE, Shakhnovich V, Edginton A, Balevic SJ, James LP, Collier DN, Anand R, Gonzalez D; Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. Thompson EJ, et al. Among authors: shakhnovich v. CPT Pharmacometrics Syst Pharmacol. 2024 Aug;13(8):1394-1408. doi: 10.1002/psp4.13167. Epub 2024 Jun 4. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38837864 Free PMC article. Clinical Trial.
Exploring the Influence of Obesity and CYP2 C19 Genotype on Lansoprazole Pharmacokinetics in Pediatric Patients: A Population Modeling Approach.
Helfer VE, Gonzalez D, Kyler KE, Dunlap TC, Williams V, Radford J, Selvarangan R, Sasidharan A, Chan S, Artz N, Retke B, Toren P, Gibson K, Shakhnovich V. Helfer VE, et al. Among authors: shakhnovich v. Clin Pharmacokinet. 2025 Jul;64(7):1047-1059. doi: 10.1007/s40262-025-01517-0. Epub 2025 May 16. Clin Pharmacokinet. 2025. PMID: 40379961
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing.
Lima JJ, Thomas CD, Barbarino J, Desta Z, Van Driest SL, El Rouby N, Johnson JA, Cavallari LH, Shakhnovich V, Thacker DL, Scott SA, Schwab M, Uppugunduri CRS, Formea CM, Franciosi JP, Sangkuhl K, Gaedigk A, Klein TE, Gammal RS, Furuta T. Lima JJ, et al. Among authors: shakhnovich v. Clin Pharmacol Ther. 2021 Jun;109(6):1417-1423. doi: 10.1002/cpt.2015. Epub 2020 Sep 20. Clin Pharmacol Ther. 2021. PMID: 32770672 Free PMC article.
70 results