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Page 1
Rigor and reproducibility in human brain organoid research: Where we are and where we need to go.
Sandoval SO, Cappuccio G, Kruth K, Osenberg S, Khalil SM, Méndez-Albelo NM, Padmanabhan K, Wang D, Niciu MJ, Bhattacharyya A, Stein JL, Sousa AMM, Waxman EA, Buttermore ED, Whye D, Sirois CL; Cross-IDDRC Human Stem Cell Consortium; Williams A, Maletic-Savatic M, Zhao X. Sandoval SO, et al. Among authors: sousa amm. Stem Cell Reports. 2024 Jun 11;19(6):796-816. doi: 10.1016/j.stemcr.2024.04.008. Epub 2024 May 16. Stem Cell Reports. 2024. PMID: 38759644 Free PMC article. Review.
Transcriptome and epigenome landscape of human cortical development modeled in organoids.
Amiri A, Coppola G, Scuderi S, Wu F, Roychowdhury T, Liu F, Pochareddy S, Shin Y, Safi A, Song L, Zhu Y, Sousa AMM; PsychENCODE Consortium; Gerstein M, Crawford GE, Sestan N, Abyzov A, Vaccarino FM. Amiri A, et al. Among authors: sousa amm. Science. 2018 Dec 14;362(6420):eaat6720. doi: 10.1126/science.aat6720. Science. 2018. PMID: 30545853 Free PMC article.
Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons.
Li Z, Kaur N, Santpere G, Muchnik SK, Sindhu SK, Qi C, Shibata M, Clément O, Klarić TS, de Martin X, Luria V, Cho H, Li M, Shibata A, Tebbenkamp ATN, Ma S, Han W, Kim SK, Pochareddy S, Duy PQ, Xing X, Bao Y, Xu X, Gladwyn-Ng IE, Cullen HD, Paolino A, Fenlon LR, Kozulin P, Suárez R, Risgaard RD, Gulden FO, Karger A, Suzuki IK, Hirata T, Gobeske KT, Richards LJ, Sousa AMM, Heng JI, Sestan N. Li Z, et al. Among authors: sousa amm. bioRxiv [Preprint]. 2025 May 21:2025.05.20.652233. doi: 10.1101/2025.05.20.652233. bioRxiv. 2025. PMID: 40475427 Free PMC article. Preprint.
Multimodal analyses reveal genes driving electrophysiological maturation of neurons in the primate prefrontal cortex.
Gao Y, Dong Q, Arachchilage KH, Risgaard RD, Syed M, Sheng J, Schmidt DK, Jin T, Liu S, Sandoval SO, Knaack S, Eckholm MT, Chen RJ, Guo Y, Doherty D, Glass I, Levine JE, Wang D, Chang Q, Zhao X, Sousa AMM. Gao Y, et al. Among authors: sousa amm. Neuron. 2025 May 14:S0896-6273(25)00308-3. doi: 10.1016/j.neuron.2025.04.025. Online ahead of print. Neuron. 2025. PMID: 40398411
A human-specific enhancer fine-tunes radial glia potency and corticogenesis.
Liu J, Mosti F, Zhao HT, Lollis D, Sotelo-Fonseca JE, Escobar-Tomlienovich CF, Musso CM, Mao Y, Massri AJ, Doll HM, Moss ND, Sousa AMM, Wray GA, Schmidt ERE, Silver DL. Liu J, et al. Among authors: sousa amm. Nature. 2025 May 14. doi: 10.1038/s41586-025-09002-1. Online ahead of print. Nature. 2025. PMID: 40369080
66 results