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One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids.
Geurts MH, Gandhi S, Boretto MG, Akkerman N, Derks LLM, van Son G, Celotti M, Harshuk-Shabso S, Peci F, Begthel H, Hendriks D, Schürmann P, Andersson-Rolf A, Chuva de Sousa Lopes SM, van Es JH, van Boxtel R, Clevers H. Geurts MH, et al. Among authors: chuva de sousa lopes sm. Nat Commun. 2023 Aug 17;14(1):4998. doi: 10.1038/s41467-023-40701-3. Nat Commun. 2023. PMID: 37591832 Free PMC article.
Human fetal brain self-organizes into long-term expanding organoids.
Hendriks D, Pagliaro A, Andreatta F, Ma Z, van Giessen J, Massalini S, López-Iglesias C, van Son GJF, DeMartino J, Damen JMA, Zoutendijk I, Staliarova N, Bredenoord AL, Holstege FCP, Peters PJ, Margaritis T, Chuva de Sousa Lopes S, Wu W, Clevers H, Artegiani B. Hendriks D, et al. Among authors: chuva de sousa lopes s. Cell. 2024 Feb 1;187(3):712-732.e38. doi: 10.1016/j.cell.2023.12.012. Epub 2024 Jan 8. Cell. 2024. PMID: 38194967 Free article.
Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages.
Andersson-Rolf A, Groot K, Korving J, Begthel H, Hanegraaf MAJ, VanInsberghe M, Salmén F, van den Brink S, Lopez-Iglesias C, Peters PJ, Krueger D, Beumer J, Geurts MH, Alemany A, Gehart H, Carlotti F, de Koning EJP, Chuva de Sousa Lopes SM, van Oudenaarden A, van Es JH, Clevers H. Andersson-Rolf A, et al. Among authors: chuva de sousa lopes sm. Cell. 2024 Dec 26;187(26):7394-7413.e22. doi: 10.1016/j.cell.2024.10.044. Epub 2024 Dec 2. Cell. 2024. PMID: 39626658 Free article.
An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying SFPQ-TFE3 driven translocation RCC.
Ganpat MMP, Morales-Rodriguez F, Pham N, Lijnzaad P, de Souza T, Derakhshan S, Fumagalli A, Zeller P, Balwierz A, Ayyildiz D, van den Heuvel-Eibrink MM, de Krijger RR, van Oudenaarden A, Margaritis T, Chuva de Sousa Lopes SM, Drost J. Ganpat MMP, et al. Among authors: chuva de sousa lopes sm. iScience. 2025 Mar 1;28(4):112122. doi: 10.1016/j.isci.2025.112122. eCollection 2025 Apr 18. iScience. 2025. PMID: 40463960 Free PMC article.
Generating high-fidelity cochlear organoids from human pluripotent stem cells.
Moore ST, Nakamura T, Nie J, Solivais AJ, Aristizábal-Ramírez I, Ueda Y, Manikandan M, Reddy VS, Romano DR, Hoffman JR, Perrin BJ, Nelson RF, Frolenkov GI, Chuva de Sousa Lopes SM, Hashino E. Moore ST, et al. Cell Stem Cell. 2023 Jul 6;30(7):950-961.e7. doi: 10.1016/j.stem.2023.06.006. Cell Stem Cell. 2023. PMID: 37419105 Free PMC article.
Stem cell-derived gametes: what to expect when expecting their clinical introduction.
de Bruin IJ, Spaander MM, Harmsen S, Edelenbosch R, Ploem MC, Dartée N, Cardoso Vaz Santos M, Lakshmipathi M, Mulder CL, van Pelt AMM, Baarends WM, Chuva de Sousa Lopes SM, de Wert GMWR, Segers S, Hamer G, Pereira Daoud AM. de Bruin IJ, et al. Among authors: chuva de sousa lopes sm. Hum Reprod. 2025 Jul 2:deaf123. doi: 10.1093/humrep/deaf123. Online ahead of print. Hum Reprod. 2025. PMID: 40605085
158 results